The injectable contraceptives depot medroxyprogesterone acetate and norethisterone enanthate substantially and differentially decrease testosterone and sex hormone binding globulin levels: A secondary study from the WHICH randomized clinical trial

• Chanel Avenant ,

  Contributed equally to this work with: Chanel Avenant, Mandisa Singata-Madliki

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa

  ⨯
• Mandisa Singata-Madliki ,

  Contributed equally to this work with: Chanel Avenant, Mandisa Singata-Madliki

  Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing

  Affiliation Effective Care Research Unit, Eastern Cape Department of Health/Universities of the Witwatersrand and Fort Hare, East London, South Africa

  ⨯
• Alexis J. Bick,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa

  ⨯
• Donita Africander,

  Roles Writing – original draft, Writing – review & editing

  Affiliation Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa

  ⨯
• Yusentha Balakrishna,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Biostatistics Research Unit, South African Medical Research Council, Durban, South Africa

  ⨯
• Karl-Heinz Storbeck,

  Roles Methodology, Writing – review & editing

  Affiliation Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa

  https://orcid.org/0000-0003-1669-6383

  ⨯
• Johnson M. Moliki,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa

  ⨯
• Sigcinile Dlamini,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa

  ⨯
• Salndave Skosana †,

  † Deceased.

  Roles Methodology

  Affiliation Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa

  ⨯
• Jenni Smit,

  Roles Resources, Writing – review & editing

  Affiliation Wits MRU (MatCH Research Unit), Department of Obstetrics and Gynecology, Faculty of Health Sciences, University of the Witwatersrand, Durban, South Africa

  ⨯
• Mags Beksinska,

  Roles Resources, Writing – review & editing

  Affiliation Wits MRU (MatCH Research Unit), Department of Obstetrics and Gynecology, Faculty of Health Sciences, University of the Witwatersrand, Durban, South Africa

  ⨯
• Ivana Beesham,

  Roles Resources, Writing – review & editing

  Affiliation Wits MRU (MatCH Research Unit), Department of Obstetrics and Gynecology, Faculty of Health Sciences, University of the Witwatersrand, Durban, South Africa

  ⨯
• Ishen Seocharan,

  Roles Data curation

  Affiliation Biostatistics Research Unit, South African Medical Research Council, Durban, South Africa

  ⨯
• Joanne Batting,

  Roles Resources, Writing – review & editing

  Affiliation Effective Care Research Unit, Eastern Cape Department of Health/Universities of the Witwatersrand and Fort Hare, East London, South Africa

  ⨯
• George J. Hofmeyr ,

  Roles Conceptualization, Writing – original draft, Writing – review & editing

  ¶‡ GJH and JPH also contributed equally to this work.

  Affiliations Effective Care Research Unit, Eastern Cape Department of Health/Universities of the Witwatersrand and Fort Hare, East London, South Africa, Walter Sisulu University, East London, South Africa, Department of Obstetrics and Gynecology, University of Botswana, Gaborone, Botswana

  ⨯
•  [ ... ],
• Janet P. Hapgood

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: Janet.Hapgood@uct.ac.za

  ¶‡ GJH and JPH also contributed equally to this work.

  Affiliations Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa

  https://orcid.org/0000-0002-4414-4861

  ⨯
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