Assessment of the antileishmanial activity of diallyl sulfide combined with meglumine antimoniate on Leishmania major: Molecular docking, in vitro, and animal model

Farzaneh Zarrinkar; Iraj Sharifi; Ehsan Salarkia; Alireza Keyhani; Zahra Babaei; Ali Khamesipour; Maryam Hakimi Parizi; Elaheh Molaakbari; Fatemeh Sharifi; Shahriar Dabiri; Mehdi Bamorovat

doi:10.1371/journal.pone.0307537

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Open Access

Peer-reviewed

Research Article

Assessment of the antileishmanial activity of diallyl sulfide combined with meglumine antimoniate on Leishmania major: Molecular docking, in vitro, and animal model

Farzaneh Zarrinkar,

Roles Methodology, Writing – original draft

Affiliation Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran
⨯
Iraj Sharifi ,

Roles Supervision, Writing – original draft

* E-mail: iraj.sharifi@yahoo.com

Affiliation Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran

https://orcid.org/0000-0002-6894-6834

⨯
Ehsan Salarkia,

Roles Formal analysis, Methodology

Affiliation Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran
⨯
Alireza Keyhani,

Roles Methodology

Affiliation Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran
⨯
Zahra Babaei,

Roles Investigation, Writing – review & editing

Affiliation Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran
⨯
Ali Khamesipour,

Roles Data curation, Validation

Affiliation Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran
⨯
Maryam Hakimi Parizi,

Roles Methodology

Affiliation Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran
⨯
Elaheh Molaakbari,

Roles Methodology, Software

Affiliation Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran
⨯
Fatemeh Sharifi,

Roles Methodology

Affiliation Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran
⨯
Shahriar Dabiri,

Roles Visualization

Affiliation Afzalipour School of Medicine and Pathology and Stem Cells Research Center, Kerman University of Medical Sciences, Kerman, Iran
⨯
Mehdi Bamorovat

Roles Writing – review & editing

Affiliation Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran
⨯

Assessment of the antileishmanial activity of diallyl sulfide combined with meglumine antimoniate on Leishmania major: Molecular docking, in vitro, and animal model

Farzaneh Zarrinkar,
Iraj Sharifi,
Ehsan Salarkia,
Alireza Keyhani,
Zahra Babaei,
Ali Khamesipour,
Maryam Hakimi Parizi,
Elaheh Molaakbari,
Fatemeh Sharifi,
Shahriar Dabiri

Published: August 30, 2024
https://doi.org/10.1371/journal.pone.0307537

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