Structural and biochemical investigation into stable FGF2 mutants with novel mutation sites and hydrophobic replacements for surface-exposed cysteines

• Young Jun An ,

  Contributed equally to this work with: Young Jun An, Ye-Eun Jung

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Marine Biotechnology & Bioresource Research Department, Korea Institute of Ocean Science and Technology, Busan, Republic of Korea

  https://orcid.org/0000-0001-9475-4353

  ⨯
• Ye-Eun Jung ,

  Contributed equally to this work with: Young Jun An, Ye-Eun Jung

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, Republic of Korea

  https://orcid.org/0000-0002-5329-7958

  ⨯
• Kyeong Won Lee,

  Roles Data curation, Formal analysis, Methodology, Validation

  Affiliation Marine Biotechnology & Bioresource Research Department, Korea Institute of Ocean Science and Technology, Busan, Republic of Korea

  ⨯
• Prashant Kaushal,

  Roles Data curation, Formal analysis, Methodology, Validation

  Affiliation Chemical & Biological Integrative Research Center, Korea Institute of Science and Technology, Seoul, Republic Korea

  ⨯
• In Young Ko,

  Roles Methodology, Validation

  Affiliation New Drug Development Center, Osong Medical Innovation Foundation, Cheongiu, Republic of Korea

  ⨯
• Seung Min Shin,

  Roles Methodology, Validation

  Affiliation Marine Biotechnology & Bioresource Research Department, Korea Institute of Ocean Science and Technology, Busan, Republic of Korea

  ⨯
• Sangho Ji,

  Roles Methodology, Validation

  Affiliation Department of Brain Sciences, DGIST, Daegu, Republic of Korea

  ⨯
• Wookyung Yu,

  Roles Methodology, Validation

  Affiliation Department of Brain Sciences, DGIST, Daegu, Republic of Korea

  ⨯
• Cheolju Lee,

  Roles Data curation, Formal analysis, Methodology, Validation

  Affiliation Chemical & Biological Integrative Research Center, Korea Institute of Science and Technology, Seoul, Republic Korea

  ⨯
• Won-Kyu Lee,

  Roles Data curation, Formal analysis, Methodology, Validation

  Affiliation New Drug Development Center, Osong Medical Innovation Foundation, Cheongiu, Republic of Korea

  https://orcid.org/0000-0003-4040-1100

  ⨯
• Kiweon Cha,

  Roles Data curation, Formal analysis, Methodology, Validation

  Affiliation New Drug Development Center, Osong Medical Innovation Foundation, Cheongiu, Republic of Korea

  ⨯
• Jung-Hyun Lee ,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jlee@kiost.ac.kr (JHL); chajung@ewha.ac.kr (SSC); yimh@kiost.ac.kr (HSY)

  Affiliation Marine Biotechnology & Bioresource Research Department, Korea Institute of Ocean Science and Technology, Busan, Republic of Korea

  ⨯
• Sun-Shin Cha ,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jlee@kiost.ac.kr (JHL); chajung@ewha.ac.kr (SSC); yimh@kiost.ac.kr (HSY)

  Affiliation Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, Republic of Korea

  ⨯
• Hyung-Soon Yim

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jlee@kiost.ac.kr (JHL); chajung@ewha.ac.kr (SSC); yimh@kiost.ac.kr (HSY)

  Affiliation Marine Biotechnology & Bioresource Research Department, Korea Institute of Ocean Science and Technology, Busan, Republic of Korea

  https://orcid.org/0000-0002-4820-856X

  ⨯