A statistical simulation model to guide the choices of analytical methods in arrayed CRISPR screen experiments

Chang Sik Kim; Jonathan Cairns; Valentina Quarantotti; Bogumil Kaczkowski; Yinhai Wang; Peter Konings; Xiang Zhang

doi:10.1371/journal.pone.0307445

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Open Access

Peer-reviewed

Research Article

A statistical simulation model to guide the choices of analytical methods in arrayed CRISPR screen experiments

Chang Sik Kim,

Roles Formal analysis, Visualization, Writing – original draft, Writing – review & editing

Affiliation Data Sciences & Quantitative Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, England
⨯
Jonathan Cairns,

Roles Writing – review & editing

Affiliation Data Sciences & Quantitative Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, England

https://orcid.org/0000-0002-9982-1401

⨯
Valentina Quarantotti,

Roles Formal analysis

Affiliation Functional Genomics, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, England
⨯
Bogumil Kaczkowski,

Roles Resources

Affiliation Data Sciences & Quantitative Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, England
⨯
Yinhai Wang,

Roles Resources, Writing – review & editing

Affiliation Data Sciences & Quantitative Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, England

https://orcid.org/0000-0002-3671-4932

⨯
Peter Konings,

Roles Resources, Writing – review & editing

Affiliation Data Sciences & Quantitative Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, England

https://orcid.org/0000-0002-8637-5916

⨯
Xiang Zhang

Roles Conceptualization, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: sc.xiang.zhang@gmail.com

Affiliation Data Sciences & Quantitative Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, England

https://orcid.org/0000-0002-3878-9196

⨯

A statistical simulation model to guide the choices of analytical methods in arrayed CRISPR screen experiments

Chang Sik Kim,
Jonathan Cairns,
Valentina Quarantotti,
Bogumil Kaczkowski,
Yinhai Wang,
Peter Konings,
Xiang Zhang

Published: August 20, 2024
https://doi.org/10.1371/journal.pone.0307445

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CRISPR
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Simulation and modeling
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Biomarkers
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Genetic screens
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Gene knockout
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Regression analysis
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Biochemical simulations
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Screening guidelines
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