Early administration of norepinephrine in sepsis: Multicenter randomized clinical trial (EA-NE-S-TUN) study protocol

• Ahlem Trifi ,

  Contributed equally to this work with: Ahlem Trifi, Sami Abdellatif, Nacef Mrad, Khaoula Ben Ismail, Hana Fradj, Yasmin Garbaa, Emna Ennouri, Radhouane Toumi, Oussama Jaoued, Hassen Ben Ghezala, Insaf Trabelsi, Sabrine Bradaii, Rania Ammar

  Roles Conceptualization, Data curation, Investigation, Methodology, Software, Writing – original draft

  * E-mail: trifiahlem2@gmail.com, Ahlem.trifi@fmt.utm.tn

  Affiliation Medical Intensive Care Unit (MICU), La Rabta Hospital, Tunis, Tunisia

  https://orcid.org/0000-0001-5088-2310

  ⨯
• Sami Abdellatif ,

  Contributed equally to this work with: Ahlem Trifi, Sami Abdellatif, Nacef Mrad, Khaoula Ben Ismail, Hana Fradj, Yasmin Garbaa, Emna Ennouri, Radhouane Toumi, Oussama Jaoued, Hassen Ben Ghezala, Insaf Trabelsi, Sabrine Bradaii, Rania Ammar

  Roles Conceptualization, Resources, Supervision

  Affiliation Medical Intensive Care Unit (MICU), La Rabta Hospital, Tunis, Tunisia

  ⨯
• Asma Mehdi ,

  Roles Data curation, Investigation

  ¶‡ AM, LM, ES, JBK, TM, AM, AAM, HK, NBF, MB, NB, HG, MB and FMK also contributed equally to this work.

  Affiliation Medical Intensive Care Unit (MICU), La Rabta Hospital, Tunis, Tunisia

  ⨯
• Linda Messaoud ,

  Roles Data curation, Investigation

  ¶‡ AM, LM, ES, JBK, TM, AM, AAM, HK, NBF, MB, NB, HG, MB and FMK also contributed equally to this work.

  Affiliation Medical Intensive Care Unit (MICU), La Rabta Hospital, Tunis, Tunisia

  ⨯
• Eya Seghir ,

  Roles Data curation, Investigation

  ¶‡ AM, LM, ES, JBK, TM, AM, AAM, HK, NBF, MB, NB, HG, MB and FMK also contributed equally to this work.

  Affiliation Medical Intensive Care Unit (MICU), La Rabta Hospital, Tunis, Tunisia

  ⨯
• Nacef Mrad ,

  Contributed equally to this work with: Ahlem Trifi, Sami Abdellatif, Nacef Mrad, Khaoula Ben Ismail, Hana Fradj, Yasmin Garbaa, Emna Ennouri, Radhouane Toumi, Oussama Jaoued, Hassen Ben Ghezala, Insaf Trabelsi, Sabrine Bradaii, Rania Ammar

  Roles Data curation, Investigation

  Affiliation MICU, Abderrahmen Mami-hospital, Ariana, Tunisia

  ⨯
• Jalila Ben Khelil ,

  Roles Conceptualization, Validation, Writing – review & editing

  ¶‡ AM, LM, ES, JBK, TM, AM, AAM, HK, NBF, MB, NB, HG, MB and FMK also contributed equally to this work.

  Affiliation MICU, Abderrahmen Mami-hospital, Ariana, Tunisia

  ⨯
• Khaoula Ben Ismail ,

  Contributed equally to this work with: Ahlem Trifi, Sami Abdellatif, Nacef Mrad, Khaoula Ben Ismail, Hana Fradj, Yasmin Garbaa, Emna Ennouri, Radhouane Toumi, Oussama Jaoued, Hassen Ben Ghezala, Insaf Trabelsi, Sabrine Bradaii, Rania Ammar

  Roles Formal analysis, Investigation

  Affiliation MICU, Zaghouan Regional Hospital, Zaghouan, Tunisia

  ⨯
• Takwa Merhaben ,

  Roles Formal analysis, Investigation, Methodology

  ¶‡ AM, LM, ES, JBK, TM, AM, AAM, HK, NBF, MB, NB, HG, MB and FMK also contributed equally to this work.

  Affiliation MICU, Zaghouan Regional Hospital, Zaghouan, Tunisia

  ⨯
• Hana Fradj ,

  Contributed equally to this work with: Ahlem Trifi, Sami Abdellatif, Nacef Mrad, Khaoula Ben Ismail, Hana Fradj, Yasmin Garbaa, Emna Ennouri, Radhouane Toumi, Oussama Jaoued, Hassen Ben Ghezala, Insaf Trabelsi, Sabrine Bradaii, Rania Ammar

  Roles Investigation, Methodology

  Affiliation Severe Burns Center, Ben Arous, Tunisia

  ⨯
• Amel Mokline ,

  Roles Formal analysis, Methodology

  ¶‡ AM, LM, ES, JBK, TM, AM, AAM, HK, NBF, MB, NB, HG, MB and FMK also contributed equally to this work.

  Affiliation Severe Burns Center, Ben Arous, Tunisia

  ⨯
• Amen Allah Messaadi ,

  Roles Software, Supervision, Validation, Writing – review & editing

  ¶‡ AM, LM, ES, JBK, TM, AM, AAM, HK, NBF, MB, NB, HG, MB and FMK also contributed equally to this work.

  Affiliation Severe Burns Center, Ben Arous, Tunisia

  ⨯
• Hyem Khiari ,

  Roles Methodology

  ¶‡ AM, LM, ES, JBK, TM, AM, AAM, HK, NBF, MB, NB, HG, MB and FMK also contributed equally to this work.

  Affiliation Department of Epidemiological Medicine and Statistics, Salah Azaiez Institute of Tunis, Tunis, Tunisia

  https://orcid.org/0000-0002-5145-5457

  ⨯
• Yasmin Garbaa ,

  Contributed equally to this work with: Ahlem Trifi, Sami Abdellatif, Nacef Mrad, Khaoula Ben Ismail, Hana Fradj, Yasmin Garbaa, Emna Ennouri, Radhouane Toumi, Oussama Jaoued, Hassen Ben Ghezala, Insaf Trabelsi, Sabrine Bradaii, Rania Ammar

  Roles Data curation, Investigation

  Affiliation MICU, Habib Thameur-hospital, Tunis, Tunisia

  ⨯
• Nabiha Borsali Falfoul ,

  Roles Conceptualization, Validation, Writing – review & editing

  ¶‡ AM, LM, ES, JBK, TM, AM, AAM, HK, NBF, MB, NB, HG, MB and FMK also contributed equally to this work.

  Affiliation MICU, Habib Thameur-hospital, Tunis, Tunisia

  ⨯
• Emna Ennouri ,

  Contributed equally to this work with: Ahlem Trifi, Sami Abdellatif, Nacef Mrad, Khaoula Ben Ismail, Hana Fradj, Yasmin Garbaa, Emna Ennouri, Radhouane Toumi, Oussama Jaoued, Hassen Ben Ghezala, Insaf Trabelsi, Sabrine Bradaii, Rania Ammar

  Roles Investigation, Methodology

  Affiliation MICU, Farhat Hached-hospital, Sousse, Tunisia

  https://orcid.org/0000-0001-6123-7050

  ⨯
• Radhouane Toumi ,

  Contributed equally to this work with: Ahlem Trifi, Sami Abdellatif, Nacef Mrad, Khaoula Ben Ismail, Hana Fradj, Yasmin Garbaa, Emna Ennouri, Radhouane Toumi, Oussama Jaoued, Hassen Ben Ghezala, Insaf Trabelsi, Sabrine Bradaii, Rania Ammar

  Roles Investigation, Methodology

  Affiliation MICU, Farhat Hached-hospital, Sousse, Tunisia

  ⨯
• Mohamed Boussarsar ,

  Roles Supervision, Validation, Writing – review & editing

  ¶‡ AM, LM, ES, JBK, TM, AM, AAM, HK, NBF, MB, NB, HG, MB and FMK also contributed equally to this work.

  Affiliation MICU, Farhat Hached-hospital, Sousse, Tunisia

  ⨯
• Oussama Jaoued ,

  Contributed equally to this work with: Ahlem Trifi, Sami Abdellatif, Nacef Mrad, Khaoula Ben Ismail, Hana Fradj, Yasmin Garbaa, Emna Ennouri, Radhouane Toumi, Oussama Jaoued, Hassen Ben Ghezala, Insaf Trabelsi, Sabrine Bradaii, Rania Ammar

  Roles Formal analysis, Investigation, Supervision

  Affiliation MICU,Tahar Sfar-hospital, Mahdia, Tunisia

  ⨯
• Souhail Atrous,

  Roles Formal analysis, Validation

  Affiliation MICU,Tahar Sfar-hospital, Mahdia, Tunisia

  ⨯
• Hassen Ben Ghezala ,

  Contributed equally to this work with: Ahlem Trifi, Sami Abdellatif, Nacef Mrad, Khaoula Ben Ismail, Hana Fradj, Yasmin Garbaa, Emna Ennouri, Radhouane Toumi, Oussama Jaoued, Hassen Ben Ghezala, Insaf Trabelsi, Sabrine Bradaii, Rania Ammar

  Roles Data curation

  Affiliation Urgent Medical Assistance Center, Tunis, Tunisia

  ⨯
• Nozha Brahmi ,

  Roles Conceptualization

  ¶‡ AM, LM, ES, JBK, TM, AM, AAM, HK, NBF, MB, NB, HG, MB and FMK also contributed equally to this work.

  Affiliation Urgent Medical Assistance Center, Tunis, Tunisia

  ⨯
• Insaf Trabelsi ,

  Contributed equally to this work with: Ahlem Trifi, Sami Abdellatif, Nacef Mrad, Khaoula Ben Ismail, Hana Fradj, Yasmin Garbaa, Emna Ennouri, Radhouane Toumi, Oussama Jaoued, Hassen Ben Ghezala, Insaf Trabelsi, Sabrine Bradaii, Rania Ammar

  Roles Data curation

  Affiliation MICU, Habib Bougatfa-hospital, Bizerte, Tunisia

  ⨯
• Hatem Ghadhoune ,

  Roles Conceptualization

  ¶‡ AM, LM, ES, JBK, TM, AM, AAM, HK, NBF, MB, NB, HG, MB and FMK also contributed equally to this work.

  Affiliation MICU, Habib Bougatfa-hospital, Bizerte, Tunisia

  ⨯
• Sabrine Bradaii ,

  Contributed equally to this work with: Ahlem Trifi, Sami Abdellatif, Nacef Mrad, Khaoula Ben Ismail, Hana Fradj, Yasmin Garbaa, Emna Ennouri, Radhouane Toumi, Oussama Jaoued, Hassen Ben Ghezala, Insaf Trabelsi, Sabrine Bradaii, Rania Ammar

  Roles Methodology

  Affiliation MICU, Habib Bourguiba-hospital, Sfax, Tunisia

  ⨯
• Mabrouk Bahloul ,

  Roles Writing – original draft, Writing – review & editing

  ¶‡ AM, LM, ES, JBK, TM, AM, AAM, HK, NBF, MB, NB, HG, MB and FMK also contributed equally to this work.

  Affiliation MICU, Habib Bourguiba-hospital, Sfax, Tunisia

  ⨯
• Rania Ammar ,

  Contributed equally to this work with: Ahlem Trifi, Sami Abdellatif, Nacef Mrad, Khaoula Ben Ismail, Hana Fradj, Yasmin Garbaa, Emna Ennouri, Radhouane Toumi, Oussama Jaoued, Hassen Ben Ghezala, Insaf Trabelsi, Sabrine Bradaii, Rania Ammar

  Roles Formal analysis

  Affiliation MICU, Mahres Hospital, Sfax, Tunisia

  ⨯
•  [ ... ],
• Fatma Medhioub Kaaniche

  Roles Methodology

  ¶‡ AM, LM, ES, JBK, TM, AM, AAM, HK, NBF, MB, NB, HG, MB and FMK also contributed equally to this work.

  Affiliation MICU, Mahres Hospital, Sfax, Tunisia

  ⨯
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