Association of bradykinin receptor 2 (BDKRB2) variants with physical performance and muscle mass: Findings from the LACE sarcopenia trial

Alvin Shrestha; Tufail Bashir; Marcus Achison; Simon Adamson; Asangaedem Akpan; Terry Aspray; Alison Avenell; Margaret M. Band; Louise A. Burton; Vera Cvoro; Peter T. Donnan; Gordon W. Duncan; Jacob George; Adam L. Gordon; Celia L. Gregson; Adrian Hapca; Cheryl Hume; Thomas A. Jackson; Simon Kerr; Alixe Kilgour; Tahir Masud; Andrew McKenzie; Emma McKenzie; Harnish Patel; Kristina Pilvinyte; Helen C. Roberts; Avan A. Sayer; Christos Rossios; Karen T. Smith; Roy L. Soiza; Claire J. Steves; Allan D. Struthers; Divya Tiwari; Julie Whitney; Miles D. Witham; Paul R. Kemp

doi:10.1371/journal.pone.0307268

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Open Access

Peer-reviewed

Research Article

Association of bradykinin receptor 2 (BDKRB2) variants with physical performance and muscle mass: Findings from the LACE sarcopenia trial

Alvin Shrestha ,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

* E-mail: a.shrestha@imperial.ac.uk

Affiliations Cardiovascular and Respiratory Interface Section, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, United Kingdom, Cutrale Perioperative and Ageing Group, Department of Bioengineering, Imperial College London, London, United Kingdom

https://orcid.org/0000-0002-4032-2608

⨯
Tufail Bashir,

Roles Writing – review & editing

Affiliation Cardiovascular and Respiratory Interface Section, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, United Kingdom
⨯
Marcus Achison,

Roles Writing – review & editing

Affiliation Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), Ninewells Hospital & Medical School, University of Dundee, Dundee, United Kingdom
⨯
Simon Adamson,

Roles Writing – review & editing

Affiliation Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), Ninewells Hospital & Medical School, University of Dundee, Dundee, United Kingdom
⨯
Asangaedem Akpan,

Roles Writing – original draft

Affiliation Liverpool University Hospitals NHS FT Trust, Clinical Research Network Northwest Coast, University of Liverpool, Liverpool, United Kingdom
⨯
Terry Aspray,

Roles Writing – review & editing

Affiliation AGE Research Group, NIHR Newcastle Biomedical Research Centre, Cumbria Northumberland Tyne and Wear NHS Foundation Trust and Newcastle upon Tyne Hospitals NHS Trust, Translational Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Alison Avenell,

Roles Writing – review & editing

Affiliation Health Services Research Unit, University of Aberdeen, Aberdeen, United Kingdom
⨯
Margaret M. Band,

Roles Writing – review & editing

Affiliation Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), Ninewells Hospital & Medical School, University of Dundee, Dundee, United Kingdom
⨯
Louise A. Burton,

Roles Writing – review & editing

Affiliations Medicine for the Elderly, NHS Tayside, Dundee, United Kingdom, Ageing and Health, University of Dundee, Dundee, United Kingdom
⨯
Vera Cvoro,

Roles Writing – review & editing

Affiliations Victoria Hospital, Kirkcaldy, United Kingdom, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom
⨯
Peter T. Donnan,

Roles Writing – review & editing

Affiliation Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, United Kingdom
⨯
Gordon W. Duncan,

Roles Writing – review & editing

Affiliations Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, Medicine for the Elderly, NHS Lothian, Edinburgh, United Kingdom
⨯
Jacob George,

Roles Writing – review & editing

Affiliation Division of Molecular & Clinical Medicine, University of Dundee Medical School, Ninewells Hospital, Dundee, United Kingdom
⨯
Adam L. Gordon,

Roles Writing – review & editing

Affiliations Unit of Injury, Inflammation and Recovery, School of Medicine, University of Nottingham, Nottingham United Kingdom, NIHR Nottingham Biomedical Research Centre, Department of Medicine for the Elderly, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, United Kingdom
⨯
Celia L. Gregson,

Roles Writing – review & editing

Affiliations Musculoskeletal Research Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom, Older Person’s Unit, Royal United Hospital NHS Foundation Trust Bath, Bath, United Kingdom
⨯
Adrian Hapca,

Roles Writing – review & editing

Affiliation Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), Ninewells Hospital & Medical School, University of Dundee, Dundee, United Kingdom
⨯
Cheryl Hume,

Roles Writing – review & editing

Affiliation Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), Ninewells Hospital & Medical School, University of Dundee, Dundee, United Kingdom
⨯
Thomas A. Jackson,

Roles Writing – review & editing

Affiliation Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom
⨯
Simon Kerr,

Roles Writing – review & editing

Affiliation Department of Older People’s Medicine, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom
⨯
Alixe Kilgour,

Roles Writing – review & editing

Affiliations Medicine for the Elderly, NHS Lothian, Edinburgh, United Kingdom, Ageing and Health Research Group, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom
⨯
Tahir Masud,

Roles Writing – review & editing

Affiliation Clinical Gerontology Research Unit, Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham, United Kingdom
⨯
Andrew McKenzie,

Roles Writing – review & editing

Affiliation Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), Ninewells Hospital & Medical School, University of Dundee, Dundee, United Kingdom
⨯
Emma McKenzie,

Roles Writing – review & editing

Affiliation Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), Ninewells Hospital & Medical School, University of Dundee, Dundee, United Kingdom
⨯
Harnish Patel,

Roles Writing – review & editing

Affiliation NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHSFT, Southampton, Hampshire, United Kingdom

https://orcid.org/0000-0002-0081-1802

⨯
Kristina Pilvinyte,

Roles Writing – review & editing

Affiliation Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), Ninewells Hospital & Medical School, University of Dundee, Dundee, United Kingdom

https://orcid.org/0000-0003-1420-8075

⨯
Helen C. Roberts,

Roles Writing – review & editing

Affiliation Academic Geriatric Medicine, Mailpoint 807 Southampton General Hospital, University of Southampton, Southampton, United Kingdom
⨯
Avan A. Sayer,

Roles Conceptualization, Writing – review & editing

Affiliation AGE Research Group, NIHR Newcastle Biomedical Research Centre, Cumbria Northumberland Tyne and Wear NHS Foundation Trust and Newcastle upon Tyne Hospitals NHS Trust, Translational Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Christos Rossios,

Roles Writing – review & editing

Affiliation Cardiovascular and Respiratory Interface Section, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, United Kingdom
⨯
Karen T. Smith,

Roles Writing – review & editing

Affiliation Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), Ninewells Hospital & Medical School, University of Dundee, Dundee, United Kingdom
⨯
Roy L. Soiza,

Roles Writing – review & editing

Affiliation Ageing & Clinical Experimental Research (ACER) Group, University of Aberdeen, Aberdeen, United Kingdom

https://orcid.org/0000-0002-1397-4272

⨯
Claire J. Steves,

Roles Writing – review & editing

Affiliation Department of Twin Research and Genetic Epidemiology, King’s College London & Department of Clinical Gerontology, King’s College Hospital, London, United Kingdom
⨯
Allan D. Struthers,

Roles Writing – review & editing

Affiliation Division of Molecular & Clinical Medicine, University of Dundee Medical School, Ninewells Hospital, Dundee, United Kingdom
⨯
Divya Tiwari,

Roles Writing – review & editing

Affiliation Bournemouth University and Royal Bournemouth Hospital, Bournemouth, United Kingdom
⨯
Julie Whitney,

Roles Writing – review & editing

Affiliation School of Population Health & Environmental Sciences, King’s College London and King’s College Hospital, London, United Kingdom
⨯
Miles D. Witham,

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Writing – review & editing

Affiliation AGE Research Group, NIHR Newcastle Biomedical Research Centre, Cumbria Northumberland Tyne and Wear NHS Foundation Trust and Newcastle upon Tyne Hospitals NHS Trust, Translational Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
[ ... ],
Paul R. Kemp

Roles Conceptualization, Supervision, Visualization, Writing – review & editing

Affiliation Cardiovascular and Respiratory Interface Section, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, United Kingdom
⨯
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Association of bradykinin receptor 2 (BDKRB2) variants with physical performance and muscle mass: Findings from the LACE sarcopenia trial

Alvin Shrestha,
Tufail Bashir,
Marcus Achison,
Simon Adamson,
Asangaedem Akpan,
Terry Aspray,
Alison Avenell,
Margaret M. Band,
Louise A. Burton,
Vera Cvoro

Published: August 2, 2024
https://doi.org/10.1371/journal.pone.0307268

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