Genome-wide RNA sequencing of ocular fibroblasts from glaucomatous and normal eyes: Implications for glaucoma management

Anton W. Roodnat; Breedge Callaghan; Chelsey Doyle; Neeru A. Vallabh; Sarah D. Atkinson; Colin E. Willoughby

doi:10.1371/journal.pone.0307227

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Open Access

Peer-reviewed

Research Article

Genome-wide RNA sequencing of ocular fibroblasts from glaucomatous and normal eyes: Implications for glaucoma management

Anton W. Roodnat,

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Visualization, Writing – original draft, Writing – review & editing

Affiliation Centre for Genomic Medicine, Biomedical Sciences Research Institute, Ulster University, Coleraine, Northern Ireland, United Kingdom

https://orcid.org/0000-0002-1481-1061

⨯
Breedge Callaghan,

Roles Methodology, Project administration, Validation, Writing – review & editing

Affiliation Centre for Genomic Medicine, Biomedical Sciences Research Institute, Ulster University, Coleraine, Northern Ireland, United Kingdom
⨯
Chelsey Doyle,

Roles Data curation, Methodology, Project administration, Software, Writing – review & editing

Affiliation Centre for Genomic Medicine, Biomedical Sciences Research Institute, Ulster University, Coleraine, Northern Ireland, United Kingdom
⨯
Neeru A. Vallabh,

Roles Funding acquisition, Methodology, Project administration, Resources, Writing – review & editing

Affiliations Department of Eye and Vision Science, Insitute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom, St. Paul’s Eye Unit, Liverpool University Hospital NHS Foundation Trust, Liverpool, United Kingdom

https://orcid.org/0000-0002-0109-4112

⨯
Sarah D. Atkinson ,

Roles Conceptualization, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: c.willoughby@ulster.ac.uk (CEW); s.atkinson@ulster.ac.uk (SDA)

Affiliation Centre for Genomic Medicine, Biomedical Sciences Research Institute, Ulster University, Coleraine, Northern Ireland, United Kingdom

https://orcid.org/0000-0002-3208-8794

⨯
Colin E. Willoughby

Roles Conceptualization, Funding acquisition, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: c.willoughby@ulster.ac.uk (CEW); s.atkinson@ulster.ac.uk (SDA)

Affiliation Centre for Genomic Medicine, Biomedical Sciences Research Institute, Ulster University, Coleraine, Northern Ireland, United Kingdom

https://orcid.org/0000-0002-1246-4166

⨯

Genome-wide RNA sequencing of ocular fibroblasts from glaucomatous and normal eyes: Implications for glaucoma management

Anton W. Roodnat,
Breedge Callaghan,
Chelsey Doyle,
Neeru A. Vallabh,
Sarah D. Atkinson,
Colin E. Willoughby

Published: July 11, 2024
https://doi.org/10.1371/journal.pone.0307227

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Fibroblasts
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Glaucoma
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Gene expression
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Autophagic cell death
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Ophthalmic procedures
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Cell cycle and cell division
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