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Open Access
Peer-reviewed
Research Article
Valproic acid use is associated with diminished risk of contracting COVID-19, and diminished disease severity: Epidemiologic and in vitro analysis reveal mechanistic insights
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Amanda Watson ,
Contributed equally to this work with: Amanda Watson, Pankil Shah
Roles Formal analysis, Investigation
Affiliation Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health Science Center San Antonio, San Antonio, Texas, United States of America
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Pankil Shah ,
Contributed equally to this work with: Amanda Watson, Pankil Shah
Roles Data curation, Formal analysis
Affiliation Department of Urology, University of Texas Health Science Center San Antonio, San Antonio, Texas, United States of America
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Doug Lee,
Roles Investigation
Affiliation Department of Urology, University of Texas Health Science Center San Antonio, San Antonio, Texas, United States of America
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Sitai Liang,
Roles Investigation
Affiliation Department of Urology, University of Texas Health Science Center San Antonio, San Antonio, Texas, United States of America
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Geeta Joshi,
Roles Formal analysis, Writing – review & editing
Affiliation Department of Urology, University of Texas Health Science Center San Antonio, San Antonio, Texas, United States of America
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Ediri Metitiri,
Roles Writing – review & editing
Affiliation Department of Urology, University of Texas Health Science Center San Antonio, San Antonio, Texas, United States of America
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Wasim H. Chowdhury,
Roles Formal analysis
Affiliation Department of Urology, University of Texas Health Science Center San Antonio, San Antonio, Texas, United States of America
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Dean Bacich,
Roles Formal analysis, Investigation
Affiliation Department of Urology, University of Texas Health Science Center San Antonio, San Antonio, Texas, United States of America
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Peter Dube,
Roles Investigation
Affiliation Boehringer Ingelheim in Ames, Ames, Iowa, United States of America
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Yan Xiang,
Roles Investigation
Affiliation Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center San Antonio San Antonio, Texas, United States of America
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Daniel Hanley,
Roles Formal analysis
Affiliation Department of Neurology & Neurosurgery, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
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Luis Martinez-Sobrido,
Roles Investigation
Affiliation Texas Biomedical Research Institute, San Antonio, Texas, United States of America
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Ronald Rodriguez
Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing
* E-mail: Rodriguezr32@uthscsa.edu
Affiliation Department of Medical Education, and Department of Urology, University of Texas Health Science Center San Antonio, San Antonio, Texas, United States of America
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Valproic acid use is associated with diminished risk of contracting COVID-19, and diminished disease severity: Epidemiologic and in vitro analysis reveal mechanistic insights
- Amanda Watson,
- Pankil Shah,
- Doug Lee,
- Sitai Liang,
- Geeta Joshi,
- Ediri Metitiri,
- Wasim H. Chowdhury,
- Dean Bacich,
- Peter Dube,
- Yan Xiang
- Published: August 2, 2024
- https://doi.org/10.1371/journal.pone.0307154