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Open Access
Peer-reviewed
Research Article
3-nitropyridine analogues as novel microtubule-targeting agents
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Jean Herman ,
Contributed equally to this work with: Jean Herman, Els Vanstreels
Roles Project administration, Writing – original draft
Affiliations 4AZA Biosciences, Leuven, Belgium, Interface Valorisation Platform (IVAP), KU Leuven, Leuven, Belgium, Laboratory of Molecular Immunology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium, Department of Pediatric Nephrology and Solid Organ Transplantation, University Hospitals Leuven, Leuven, Belgium
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Els Vanstreels ,
Contributed equally to this work with: Jean Herman, Els Vanstreels
Roles Data curation, Investigation, Writing – original draft
Affiliation Molecular Genetics and Therapeutics in Virology and Oncology Research Group, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium
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Dorothée Bardiot ,
Roles Investigation
Current address: CISTIM Leuven vzw, Leuven, Belgium
¶‡ DB, AEP, NG and LJG also contributed equally to this work.
Affiliation 4AZA Biosciences, Leuven, Belgium
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Andrea E. Prota ,
Roles Data curation, Investigation, Writing – original draft
¶‡ DB, AEP, NG and LJG also contributed equally to this work.
Affiliation Laboratory of Biomolecular Research, Center for Life Sciences, Paul Scherrer Institut, Würenlingen, Switzerland
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Natacha Gaillard ,
Roles Data curation, Investigation, Writing – original draft
¶‡ DB, AEP, NG and LJG also contributed equally to this work.
Affiliation Laboratory of Biomolecular Research, Center for Life Sciences, Paul Scherrer Institut, Würenlingen, Switzerland
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Ling-Jie Gao ,
Roles Investigation, Writing – original draft
¶‡ DB, AEP, NG and LJG also contributed equally to this work.
Affiliations 4AZA Biosciences, Leuven, Belgium, Interface Valorisation Platform (IVAP), KU Leuven, Leuven, Belgium, Laboratory of Medicinal Chemistry, Department of Pharmaceutical and Pharmacological Sciences, Rega Institute, KU Leuven, Leuven, Belgium
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Thomas Vercruysse,
Roles Data curation, Investigation
Affiliation Molecular Genetics and Therapeutics in Virology and Oncology Research Group, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium
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Leentje Persoons,
Roles Investigation
Affiliation Molecular Genetics and Therapeutics in Virology and Oncology Research Group, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium
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Tinne Daems,
Roles Data curation, Investigation
Current address: Aminolabs, Hasselt Research Campus 6, Hasselt, Belgium
Affiliation 4AZA Biosciences, Leuven, Belgium
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Mark Waer,
Roles Conceptualization, Resources, Writing – review & editing
Affiliations 4AZA Biosciences, Leuven, Belgium, Interface Valorisation Platform (IVAP), KU Leuven, Leuven, Belgium, Laboratory of Molecular Immunology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium
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Piet Herdewijn,
Roles Conceptualization, Resources, Supervision, Writing – review & editing
Affiliations 4AZA Biosciences, Leuven, Belgium, Interface Valorisation Platform (IVAP), KU Leuven, Leuven, Belgium, Laboratory of Medicinal Chemistry, Department of Pharmaceutical and Pharmacological Sciences, Rega Institute, KU Leuven, Leuven, Belgium
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Thierry Louat,
Roles Data curation, Investigation, Project administration, Writing – original draft
Affiliations 4AZA Biosciences, Leuven, Belgium, Interface Valorisation Platform (IVAP), KU Leuven, Leuven, Belgium
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Michel O. Steinmetz,
Roles Resources, Supervision, Writing – review & editing
Affiliations Laboratory of Biomolecular Research, Center for Life Sciences, Paul Scherrer Institut, Würenlingen, Switzerland, University of Basel, Basel, Switzerland
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Steven De Jonghe,
Roles Project administration, Supervision, Writing – original draft
Affiliations 4AZA Biosciences, Leuven, Belgium, Interface Valorisation Platform (IVAP), KU Leuven, Leuven, Belgium, Molecular Structural and Translational Virology Research Group, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium
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Ben Sprangers,
Roles Conceptualization, Data curation, Resources, Supervision, Writing – original draft, Writing – review & editing
Affiliations Interface Valorisation Platform (IVAP), KU Leuven, Leuven, Belgium, Laboratory of Molecular Immunology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium, Department of Nephrology, University Hospitals Leuven, Leuven, Belgium
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Dirk Daelemans
Roles Conceptualization, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: dirk.daelemans@kuleuven.be
Affiliation Molecular Genetics and Therapeutics in Virology and Oncology Research Group, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium
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3-nitropyridine analogues as novel microtubule-targeting agents
- Jean Herman,
- Els Vanstreels,
- Dorothée Bardiot,
- Andrea E. Prota,
- Natacha Gaillard,
- Ling-Jie Gao,
- Thomas Vercruysse,
- Leentje Persoons,
- Tinne Daems,
- Mark Waer
- Published: November 7, 2024
- https://doi.org/10.1371/journal.pone.0307153