Identification of small molecule agonists of fetal hemoglobin expression for the treatment of sickle cell disease

Jian-Ping Yang; Rachel Toughiri; Anshu P. Gounder; Dan Scheibe; Matt Petrus; Sarah J. Fink; Sebastien Vallee; Jon Kenniston; Nikolaos Papaioannou; Steve Langston; Narender R. Gavva; Shane R. Horman

doi:10.1371/journal.pone.0307049

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Open Access

Peer-reviewed

Research Article

Identification of small molecule agonists of fetal hemoglobin expression for the treatment of sickle cell disease

Jian-Ping Yang,

Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliation Takeda Development Center Americas, Inc., San Diego, California, United States of America
⨯
Rachel Toughiri,

Roles Investigation, Methodology

Affiliation Takeda Development Center Americas, Inc., San Diego, California, United States of America
⨯
Anshu P. Gounder,

Roles Investigation, Methodology

Affiliation Takeda Development Center Americas, Inc., San Diego, California, United States of America
⨯
Dan Scheibe,

Roles Resources, Software

Affiliation Takeda Development Center Americas, Inc., San Diego, California, United States of America
⨯
Matt Petrus,

Roles Data curation, Investigation, Methodology, Software

Affiliation Takeda Development Center Americas, Inc., San Diego, California, United States of America
⨯
Sarah J. Fink,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Takeda Development Center Americas, Inc., Cambridge, Massachusetts, United States of America

https://orcid.org/0000-0003-2990-2625

⨯
Sebastien Vallee,

Roles Conceptualization, Formal analysis, Supervision, Writing – review & editing

Affiliation Takeda Development Center Americas, Inc., Cambridge, Massachusetts, United States of America
⨯
Jon Kenniston,

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliation Takeda Development Center Americas, Inc., Cambridge, Massachusetts, United States of America
⨯
Nikolaos Papaioannou,

Roles Conceptualization, Funding acquisition, Supervision

Affiliation Takeda Development Center Americas, Inc., Cambridge, Massachusetts, United States of America

https://orcid.org/0000-0002-2516-8497

⨯
Steve Langston,

Roles Supervision, Writing – review & editing

Affiliation Takeda Development Center Americas, Inc., Cambridge, Massachusetts, United States of America
⨯
Narender R. Gavva,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Takeda Development Center Americas, Inc., San Diego, California, United States of America
⨯
Shane R. Horman

Roles Conceptualization, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: shanehorman@gmail.com

Affiliation Takeda Development Center Americas, Inc., San Diego, California, United States of America

https://orcid.org/0000-0002-4291-2126

⨯

Identification of small molecule agonists of fetal hemoglobin expression for the treatment of sickle cell disease

Jian-Ping Yang,
Rachel Toughiri,
Anshu P. Gounder,
Dan Scheibe,
Matt Petrus,
Sarah J. Fink,
Sebastien Vallee,
Jon Kenniston,
Nikolaos Papaioannou,
Steve Langston

Published: November 6, 2024
https://doi.org/10.1371/journal.pone.0307049

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Cell differentiation
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Small molecules
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