Polyploid giant cancer cells induced by Docetaxel exhibit a senescence phenotype with the expression of stem cell markers in ovarian cancer cells

Song Zhao; Lili Wang; Mingyue Ouyang; Sining Xing; Shuo Liu; Lingyan Sun; Huiying Yu

doi:10.1371/journal.pone.0306969

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Peer-reviewed

Research Article

Polyploid giant cancer cells induced by Docetaxel exhibit a senescence phenotype with the expression of stem cell markers in ovarian cancer cells

Song Zhao,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Laboratory of Basic Medicine, General Hospital of Northern Theater Command, Shenyang, China
⨯
Lili Wang,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Supervision, Validation, Writing – review & editing

Affiliation Laboratory of Basic Medicine, General Hospital of Northern Theater Command, Shenyang, China
⨯
Mingyue Ouyang,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Laboratory of Basic Medicine, General Hospital of Northern Theater Command, Shenyang, China
⨯
Sining Xing,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Laboratory of Basic Medicine, General Hospital of Northern Theater Command, Shenyang, China
⨯
Shuo Liu,

Roles Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Laboratory of Basic Medicine, General Hospital of Northern Theater Command, Shenyang, China
⨯
Lingyan Sun,

Roles Data curation, Writing – original draft, Writing – review & editing

Affiliation Laboratory of Basic Medicine, General Hospital of Northern Theater Command, Shenyang, China
⨯
Huiying Yu

Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: hyingy@sina.com

Affiliation Laboratory of Basic Medicine, General Hospital of Northern Theater Command, Shenyang, China

https://orcid.org/0000-0002-8703-9754

⨯

Polyploid giant cancer cells induced by Docetaxel exhibit a senescence phenotype with the expression of stem cell markers in ovarian cancer cells

Song Zhao,
Lili Wang,
Mingyue Ouyang,
Sining Xing,
Shuo Liu,
Lingyan Sun,
Huiying Yu

Published: July 11, 2024
https://doi.org/10.1371/journal.pone.0306969

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Cell cycle and cell division
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Cancers and neoplasms
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Ovarian cancer
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Polyploidy
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Membrane potential
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