Excitatory to inhibitory synaptic ratios are unchanged at presymptomatic stages in multiple models of ALS

Calum Bonthron; Sarah Burley; Matthew J. Broadhead; Vanya Metodieva; Seth G. N. Grant; Siddharthan Chandran; Gareth B. Miles

doi:10.1371/journal.pone.0306423

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Open Access

Peer-reviewed

Research Article

Excitatory to inhibitory synaptic ratios are unchanged at presymptomatic stages in multiple models of ALS

Calum Bonthron,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation School of Psychology and Neuroscience, University of St Andrews, St Andrews, United Kingdom

https://orcid.org/0009-0004-8409-1890

⨯
Sarah Burley,

Roles Conceptualization, Methodology, Supervision

Affiliations School of Psychology and Neuroscience, University of St Andrews, St Andrews, United Kingdom, School of Biology, University of St Andrews, St Andrews, United Kingdom
⨯
Matthew J. Broadhead,

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliation School of Psychology and Neuroscience, University of St Andrews, St Andrews, United Kingdom
⨯
Vanya Metodieva,

Roles Methodology

Affiliations School of Biology, University of St Andrews, St Andrews, United Kingdom, Centre of Biophotonics, University of St Andrews, St Andrews, United Kingdom

https://orcid.org/0000-0003-0788-3080

⨯
Seth G. N. Grant,

Roles Funding acquisition, Methodology

Affiliations Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, Simons Initiative for the Developing Brain (SIDB), Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom
⨯
Siddharthan Chandran,

Roles Funding acquisition, Methodology

Affiliations Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, Simons Initiative for the Developing Brain (SIDB), Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, UK Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, United Kingdom, Patrick Wild Centre, University of Edinburgh, Edinburgh, United Kingdom
⨯
Gareth B. Miles

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: gbm4@st-andrews.ac.uk

Affiliation School of Psychology and Neuroscience, University of St Andrews, St Andrews, United Kingdom
⨯

Excitatory to inhibitory synaptic ratios are unchanged at presymptomatic stages in multiple models of ALS

Calum Bonthron,
Sarah Burley,
Matthew J. Broadhead,
Vanya Metodieva,
Seth G. N. Grant,
Siddharthan Chandran,
Gareth B. Miles

Published: August 1, 2024
https://doi.org/10.1371/journal.pone.0306423

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