Anti-CTLA-4 treatment suppresses hepatocellular carcinoma growth through Th1-mediated cell cycle arrest and apoptosis

• Hitomi Morihara ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft

  * E-mail: hitomi.morihara@shionogi.co.jp

  Affiliations Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan, Laboratory for Bio-Drug Discovery, Shionogi & Co., Ltd., Osaka, Japan

  https://orcid.org/0009-0005-5799-1532

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• Tomomi Yamada,

  Roles Investigation, Resources

  Affiliation Laboratory for Bio-Drug Discovery, Shionogi & Co., Ltd., Osaka, Japan

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• Yumi Tona,

  Roles Investigation, Methodology

  Affiliation Laboratory for Bio-Drug Discovery, Shionogi & Co., Ltd., Osaka, Japan

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• Marina Akasaka,

  Roles Investigation, Resources

  Affiliation Laboratory for Bio-Drug Discovery, Shionogi & Co., Ltd., Osaka, Japan

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• Hirohisa Okuyama,

  Roles Methodology, Resources

  Affiliation Laboratory for Bio-Drug Discovery, Shionogi & Co., Ltd., Osaka, Japan

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• Natsumi Chatani,

  Roles Investigation, Resources

  Affiliation Laboratory for Bio-Drug Discovery, Shionogi & Co., Ltd., Osaka, Japan

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• Satomi Shinonome,

  Roles Methodology, Resources

  Affiliation Laboratory for Bio-Drug Discovery, Shionogi & Co., Ltd., Osaka, Japan

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• Azumi Ueyama,

  Roles Writing – review & editing

  Affiliation Laboratory for Bio-Drug Discovery, Shionogi & Co., Ltd., Osaka, Japan

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• Kenji Kuwabara,

  Roles Funding acquisition, Supervision

  Affiliation Laboratory for Bio-Drug Discovery, Shionogi & Co., Ltd., Osaka, Japan

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• Yasushi Fujio

  Roles Supervision, Writing – review & editing

  Affiliation Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan

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