A novel TREX1 inhibitor, VB-85680, upregulates cellular interferon responses

• Stephen Flowers ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: sflowers@mdlab.com

  Affiliation Oncoveda, A Division of Genesis Research & Development Institute, LLC, Hamilton, New Jersey, United States of America

  https://orcid.org/0009-0007-4533-0942

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• Brenda A. Petronella,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Venenum Biodesign, LLC, and Genesis Drug Discovery & Development, LLC, Hamilton, New Jersey, United States of America

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• Michael S. McQueney,

  Roles Conceptualization, Project administration, Supervision, Writing – review & editing

  Affiliation Oncoveda, A Division of Genesis Research & Development Institute, LLC, Hamilton, New Jersey, United States of America

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• Barbara Fanelli,

  Roles Investigation

  Affiliation Oncoveda, A Division of Genesis Research & Development Institute, LLC, Hamilton, New Jersey, United States of America

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• Warren Eisenberg,

  Roles Investigation

  Affiliation Venenum Biodesign, LLC, and Genesis Drug Discovery & Development, LLC, Hamilton, New Jersey, United States of America

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• Albert Uveges,

  Roles Investigation

  Affiliation Venenum Biodesign, LLC, and Genesis Drug Discovery & Development, LLC, Hamilton, New Jersey, United States of America

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• Allison L. Roden,

  Roles Investigation

  Affiliation Oncoveda, A Division of Genesis Research & Development Institute, LLC, Hamilton, New Jersey, United States of America

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• Scott Salowe,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – review & editing

  Affiliation Venenum Biodesign, LLC, and Genesis Drug Discovery & Development, LLC, Hamilton, New Jersey, United States of America

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• Venu Bommireddy,

  Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

  Affiliation Oncoveda, A Division of Genesis Research & Development Institute, LLC, Hamilton, New Jersey, United States of America

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• Jeffrey J. Letourneau,

  Roles Conceptualization, Formal analysis, Resources, Writing – review & editing

  Affiliation Venenum Biodesign, LLC, and Genesis Drug Discovery & Development, LLC, Hamilton, New Jersey, United States of America

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• Chia-Yu Huang,

  Roles Conceptualization, Project administration, Supervision

  Affiliation Venenum Biodesign, LLC, and Genesis Drug Discovery & Development, LLC, Hamilton, New Jersey, United States of America

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• James R. Beasley

  Roles Conceptualization, Project administration, Supervision

  Affiliation Venenum Biodesign, LLC, and Genesis Drug Discovery & Development, LLC, Hamilton, New Jersey, United States of America

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