Remdesivir alleviates skin fibrosis by suppressing TGF-β1 signaling pathway

Jianwei Zhang; Xiujun Zhang; Xiaowei Guo; Wenqi Li; Tiantian Zhang; Dan Chai; Yuming Liu; Li Chen; Xiaoyu Ai; Tianyuan Zhou; Wenguo Wei; Xiaoting Gu; Xiaohe Li; Honggang Zhou

doi:10.1371/journal.pone.0305927

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Open Access

Peer-reviewed

Research Article

Remdesivir alleviates skin fibrosis by suppressing TGF-β1 signaling pathway

Jianwei Zhang ,

Contributed equally to this work with: Jianwei Zhang, Xiujun Zhang, Xiaowei Guo, Wenqi Li

Roles Investigation, Software, Writing – original draft, Writing – review & editing

Affiliations State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, College of Life Sciences, Nankai University, Tianjin, China, Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, China
⨯
Xiujun Zhang ,

Contributed equally to this work with: Jianwei Zhang, Xiujun Zhang, Xiaowei Guo, Wenqi Li

Roles Investigation, Software, Writing – original draft, Writing – review & editing

Affiliation Department of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China
⨯
Xiaowei Guo ,

Contributed equally to this work with: Jianwei Zhang, Xiujun Zhang, Xiaowei Guo, Wenqi Li

Roles Data curation, Investigation, Software, Writing – original draft, Writing – review & editing

Affiliations State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, College of Life Sciences, Nankai University, Tianjin, China, Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, China
⨯
Wenqi Li ,

Contributed equally to this work with: Jianwei Zhang, Xiujun Zhang, Xiaowei Guo, Wenqi Li

Roles Data curation, Investigation, Software, Writing – original draft, Writing – review & editing

Affiliations State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, College of Life Sciences, Nankai University, Tianjin, China, Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, China
⨯
Tiantian Zhang,

Roles Conceptualization, Supervision, Visualization

Affiliations State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, College of Life Sciences, Nankai University, Tianjin, China, Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, China
⨯
Dan Chai,

Roles Conceptualization, Supervision, Visualization

Affiliations State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, College of Life Sciences, Nankai University, Tianjin, China, Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, China
⨯
Yuming Liu,

Roles Conceptualization, Visualization

Affiliations State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, College of Life Sciences, Nankai University, Tianjin, China, Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, China
⨯
Li Chen,

Roles Formal analysis, Methodology

Affiliations State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, College of Life Sciences, Nankai University, Tianjin, China, Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, China
⨯
Xiaoyu Ai,

Roles Formal analysis, Funding acquisition, Methodology

Affiliation State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, College of Life Sciences, Nankai University, Tianjin, China
⨯
Tianyuan Zhou,

Roles Methodology, Validation

Affiliation Department of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China
⨯
Wenguo Wei ,

Roles Methodology, Project administration, Resources, Validation

* E-mail: honggang.zhou@nankai.edu.cn (HZ); lixiaohe908@163.com (XL); guxiaoting320@126.com (XG); dr.wei@sohu.com (WW)

Affiliation Department of Dermatology, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China
⨯
Xiaoting Gu ,

Roles Funding acquisition, Resources

* E-mail: honggang.zhou@nankai.edu.cn (HZ); lixiaohe908@163.com (XL); guxiaoting320@126.com (XG); dr.wei@sohu.com (WW)

Affiliation State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, College of Life Sciences, Nankai University, Tianjin, China
⨯
Xiaohe Li ,

Roles Project administration, Resources, Supervision

* E-mail: honggang.zhou@nankai.edu.cn (HZ); lixiaohe908@163.com (XL); guxiaoting320@126.com (XG); dr.wei@sohu.com (WW)

Affiliations State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, College of Life Sciences, Nankai University, Tianjin, China, Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, China
⨯
Honggang Zhou

Roles Funding acquisition, Resources

* E-mail: honggang.zhou@nankai.edu.cn (HZ); lixiaohe908@163.com (XL); guxiaoting320@126.com (XG); dr.wei@sohu.com (WW)

Affiliations State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, College of Life Sciences, Nankai University, Tianjin, China, Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, China

https://orcid.org/0000-0001-8637-975X

⨯

Remdesivir alleviates skin fibrosis by suppressing TGF-β1 signaling pathway

Jianwei Zhang,
Xiujun Zhang,
Xiaowei Guo,
Wenqi Li,
Tiantian Zhang,
Dan Chai,
Yuming Liu,
Li Chen,
Xiaoyu Ai,
Tianyuan Zhou

Published: July 18, 2024
https://doi.org/10.1371/journal.pone.0305927

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Fibroblasts
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Fibrosis
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Skin tissue
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