Rosuvastatin attenuates airway inflammation and remodeling in a chronic allergic asthma model through modulation of the AMPKα signaling pathway

Lei Zhang; Feng-Ying Huang; Shu-Zhen Dai; Lin Wang; Xiangdong Zhou; Zhen-You Zheng; Qi Li; Guang-Hong Tan; Cai-Chun Wang

doi:10.1371/journal.pone.0305863

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Open Access

Peer-reviewed

Research Article

Rosuvastatin attenuates airway inflammation and remodeling in a chronic allergic asthma model through modulation of the AMPKα signaling pathway

Lei Zhang ,

Contributed equally to this work with: Lei Zhang, Feng-Ying Huang

Roles Investigation, Writing – original draft

Affiliation Department of Respiratory Medicine, The First Affiliated Hospital of Hainan Medical University & Hainan Province Clinical Medical Center of Respiratory Disease, Haikou, China
⨯
Feng-Ying Huang ,

Contributed equally to this work with: Lei Zhang, Feng-Ying Huang

Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – review & editing

Affiliation NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine & The Second Affiliated Hospital, Hainan Medical University, Haikou, China

https://orcid.org/0000-0002-1209-728X

⨯
Shu-Zhen Dai,

Roles Investigation

Affiliation NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine & The Second Affiliated Hospital, Hainan Medical University, Haikou, China
⨯
Lin Wang,

Roles Investigation

Affiliation Department of Respiratory Medicine, The First Affiliated Hospital of Hainan Medical University & Hainan Province Clinical Medical Center of Respiratory Disease, Haikou, China
⨯
Xiangdong Zhou,

Roles Investigation, Methodology, Writing – original draft

Affiliation Department of Respiratory Medicine, The First Affiliated Hospital of Hainan Medical University & Hainan Province Clinical Medical Center of Respiratory Disease, Haikou, China
⨯
Zhen-You Zheng,

Roles Funding acquisition, Investigation, Supervision, Validation

Affiliation Department of Ophthalmology, The First Affiliated Hospital of Hainan Medical University, Haikou, China
⨯
Qi Li ,

Roles Conceptualization, Funding acquisition, Writing – original draft

* E-mail: yctanyc@126.com (CCW); lqlq198210@sina.com (QL); tanhoho@163.com (GHT)

Affiliation Department of Respiratory Medicine, The First Affiliated Hospital of Hainan Medical University & Hainan Province Clinical Medical Center of Respiratory Disease, Haikou, China
⨯
Guang-Hong Tan ,

Roles Funding acquisition, Methodology, Writing – review & editing

* E-mail: yctanyc@126.com (CCW); lqlq198210@sina.com (QL); tanhoho@163.com (GHT)

Affiliation NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine & The Second Affiliated Hospital, Hainan Medical University, Haikou, China
⨯
Cai-Chun Wang

Roles Conceptualization, Methodology, Supervision, Writing – original draft

* E-mail: yctanyc@126.com (CCW); lqlq198210@sina.com (QL); tanhoho@163.com (GHT)

Affiliation Department of Respiratory Medicine, The First Affiliated Hospital of Hainan Medical University & Hainan Province Clinical Medical Center of Respiratory Disease, Haikou, China
⨯

Rosuvastatin attenuates airway inflammation and remodeling in a chronic allergic asthma model through modulation of the AMPKα signaling pathway

Lei Zhang,
Feng-Ying Huang,
Shu-Zhen Dai,
Lin Wang,
Xiangdong Zhou,
Zhen-You Zheng,
Qi Li,
Guang-Hong Tan,
Cai-Chun Wang

Published: June 24, 2024
https://doi.org/10.1371/journal.pone.0305863

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