Quercetin inhibits the epithelial-mesenchymal transition and reverses CDK4/6 inhibitor resistance in breast cancer by regulating circHIAT1/miR-19a-3p/CADM2 axis

Xiaogang Li; Chao Niu; Guoqiang Yi; Yuan Zhang; Wendi Jin; Zhiping Zhang; Wanfu Zhang; Bo Li

doi:10.1371/journal.pone.0305612

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Open Access

Peer-reviewed

Research Article

Quercetin inhibits the epithelial-mesenchymal transition and reverses CDK4/6 inhibitor resistance in breast cancer by regulating circHIAT1/miR-19a-3p/CADM2 axis

Xiaogang Li ,

Roles Funding acquisition, Investigation, Methodology, Writing – review & editing

¶‡ XL and CN are contributed equally to this work as co-first authors.

Affiliation Department of General Surgery, Affiliated Hospital of Yunnan University, Kunming, Yunnan, China
⨯
Chao Niu ,

Roles Methodology, Validation, Writing – original draft

¶‡ XL and CN are contributed equally to this work as co-first authors.

Affiliation Department of General Surgery, Affiliated Hospital of Yunnan University, Kunming, Yunnan, China
⨯
Guoqiang Yi,

Roles Data curation, Formal analysis, Investigation

Affiliation Department of General Surgery, Affiliated Hospital of Yunnan University, Kunming, Yunnan, China
⨯
Yuan Zhang,

Roles Methodology, Supervision, Validation, Writing – review & editing

Affiliation Department of General Surgery, Affiliated Hospital of Yunnan University, Kunming, Yunnan, China
⨯
Wendi Jin,

Roles Formal analysis, Software, Supervision

Affiliation Department of General Surgery, Affiliated Hospital of Yunnan University, Kunming, Yunnan, China
⨯
Zhiping Zhang,

Roles Formal analysis, Methodology, Supervision

Affiliation Department of General Surgery, Affiliated Hospital of Yunnan University, Kunming, Yunnan, China
⨯
Wanfu Zhang ,

Roles Funding acquisition, Resources, Writing – original draft

* E-mail: 920397zwf@163.com (WZ); libo2345442@126.com (BL)

Affiliation Department of General Surgery, Affiliated Hospital of Yunnan University, Kunming, Yunnan, China
⨯
Bo Li

Roles Funding acquisition, Investigation, Writing – original draft

* E-mail: 920397zwf@163.com (WZ); libo2345442@126.com (BL)

Affiliation Department of General Surgery, Affiliated Hospital of Yunnan University, Kunming, Yunnan, China

https://orcid.org/0000-0002-7678-6711

⨯

Quercetin inhibits the epithelial-mesenchymal transition and reverses CDK4/6 inhibitor resistance in breast cancer by regulating circHIAT1/miR-19a-3p/CADM2 axis

Xiaogang Li,
Chao Niu,
Guoqiang Yi,
Yuan Zhang,
Wendi Jin,
Zhiping Zhang,
Wanfu Zhang,
Bo Li

Published: July 11, 2024
https://doi.org/10.1371/journal.pone.0305612

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