Comparative proteomics reveals that fatty acid metabolism is involved in myocardial adaptation to chronic hypoxic injury

Hu Chen; Shiran Yu; Xiaoyun Zhang; Yujie Gao; Hongqi Wang; Yuankun Li; Dongsheng He; Weikun Jia

doi:10.1371/journal.pone.0305571

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Open Access

Peer-reviewed

Research Article

Comparative proteomics reveals that fatty acid metabolism is involved in myocardial adaptation to chronic hypoxic injury

Hu Chen ,

Contributed equally to this work with: Hu Chen, Shiran Yu

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: chenhu126@126.com (HC); wk_jia315@163.com (WJ)

Affiliation Department of Cardiothoracic Surgery, School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College, Chengdu, China

https://orcid.org/0000-0001-8136-7442

⨯
Shiran Yu ,

Contributed equally to this work with: Hu Chen, Shiran Yu

Roles Data curation

Affiliations Department of Cardiothoracic Surgery, School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College, Chengdu, China, Department of Thoracic Surgery, The Third Affiliated Hospital of Chengdu Medical College, Pidu District People’s Hospital, Chengdu, China
⨯
Xiaoyun Zhang,

Roles Data curation, Formal analysis

Affiliation Department of Cardiology, Pengzhou People’s Hospital, Pengzhou, China
⨯
Yujie Gao,

Roles Formal analysis, Funding acquisition

Affiliation Department of Stomatology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
⨯
Hongqi Wang,

Roles Formal analysis, Methodology

Affiliation Department of Cardiothoracic Surgery, School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
⨯
Yuankun Li,

Roles Formal analysis, Methodology

Affiliation Department of Cardiothoracic Surgery, School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
⨯
Dongsheng He,

Roles Formal analysis, Methodology

Affiliation Department of Cardiothoracic Surgery, School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
⨯
Weikun Jia

Roles Funding acquisition, Writing – review & editing

* E-mail: chenhu126@126.com (HC); wk_jia315@163.com (WJ)

Affiliation Department of Cardiothoracic Surgery, School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
⨯

Comparative proteomics reveals that fatty acid metabolism is involved in myocardial adaptation to chronic hypoxic injury

Hu Chen,
Shiran Yu,
Xiaoyun Zhang,
Yujie Gao,
Hongqi Wang,
Yuankun Li,
Dongsheng He,
Weikun Jia

Published: June 17, 2024
https://doi.org/10.1371/journal.pone.0305571

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Hypoxia
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Fatty acids
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Mitochondria
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Congenital heart defects
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Cardiomyocytes
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Protein expression
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Medical hypoxia
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Proteomic databases
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