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Open Access

Peer-reviewed

Research Article

Diazepam inhibits LPS-induced pyroptosis and inflammation and alleviates pulmonary fibrosis in mice by regulating the let-7a-5p/MYD88 axis

Duanyi Song,

Roles Conceptualization, Formal analysis, Validation, Visualization, Writing – original draft

Affiliation Department of Anesthesiology, The Second People’s Hospital of Yunnan Province, Kunming, Yunnan, China
⨯
Xuefang Tang,

Roles Formal analysis, Methodology

Affiliation Department of Anesthesiology, The Second People’s Hospital of Yunnan Province, Kunming, Yunnan, China
⨯
Juan Du,

Roles Data curation, Methodology, Software

Affiliation Department of Anesthesiology, The Second People’s Hospital of Yunnan Province, Kunming, Yunnan, China
⨯
Kang Tao,

Roles Data curation, Software

Affiliation Department of Anesthesiology, The Second People’s Hospital of Yunnan Province, Kunming, Yunnan, China
⨯
Yun Li

Roles Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: Leeliyun1@126.com

Affiliation Department of Anesthesiology, The Second People’s Hospital of Yunnan Province, Kunming, Yunnan, China

https://orcid.org/0000-0003-4381-8710

⨯

Diazepam inhibits LPS-induced pyroptosis and inflammation and alleviates pulmonary fibrosis in mice by regulating the let-7a-5p/MYD88 axis

Duanyi Song,
Xuefang Tang,
Juan Du,
Kang Tao,
Yun Li

x

Published: June 14, 2024
https://doi.org/10.1371/journal.pone.0305409

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Pulmonary fibrosis
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Diazepam
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Inflammation
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Apoptosis
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Inflammatory diseases
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Drug therapy
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Protein expression
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Cytokines
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