Network pharmacology and molecular-docking-based strategy to explore the potential mechanism of salidroside-inhibited oxidative stress in retinal ganglion cell

Peng Zhang; Hongxin Zhao; Xiangping Xia; Hua Xiao; Chong Han; Zhibo You; Junjie Wang; Fang Cao

doi:10.1371/journal.pone.0305343

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Open Access

Peer-reviewed

Research Article

Network pharmacology and molecular-docking-based strategy to explore the potential mechanism of salidroside-inhibited oxidative stress in retinal ganglion cell

Peng Zhang,

Roles Data curation, Formal analysis, Funding acquisition, Project administration, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Neurosurgery, Affiliated Hospital of Zunyi Medical University, Zunyi City, Guizhou Province, P.R. China
⨯
Hongxin Zhao,

Roles Data curation, Software, Visualization, Writing – review & editing

Affiliation Department of Neurosurgery, Affiliated Hospital of Zunyi Medical University, Zunyi City, Guizhou Province, P.R. China
⨯
Xiangping Xia,

Roles Data curation, Formal analysis, Project administration

Affiliation Department of Neurosurgery, Affiliated Hospital of Zunyi Medical University, Zunyi City, Guizhou Province, P.R. China
⨯
Hua Xiao,

Roles Validation, Visualization

Affiliation Department of Neurosurgery, Affiliated Hospital of Zunyi Medical University, Zunyi City, Guizhou Province, P.R. China
⨯
Chong Han,

Roles Software, Validation, Visualization

Affiliation Department of Neurosurgery, Affiliated Hospital of Zunyi Medical University, Zunyi City, Guizhou Province, P.R. China
⨯
Zhibo You,

Roles Software, Validation, Writing – review & editing

Affiliation Department of Neurosurgery, Affiliated Hospital of Zunyi Medical University, Zunyi City, Guizhou Province, P.R. China
⨯
Junjie Wang,

Roles Software, Writing – review & editing

Affiliation Department of Neurosurgery, Affiliated Hospital of Zunyi Medical University, Zunyi City, Guizhou Province, P.R. China
⨯
Fang Cao

Roles Data curation, Software, Visualization, Writing – review & editing

* E-mail: caof@zmu.edu.cn

Affiliation Department of Neurosurgery, Affiliated Hospital of Zunyi Medical University, Zunyi City, Guizhou Province, P.R. China

https://orcid.org/0000-0002-4900-8957

⨯

Network pharmacology and molecular-docking-based strategy to explore the potential mechanism of salidroside-inhibited oxidative stress in retinal ganglion cell

Peng Zhang,
Hongxin Zhao,
Xiangping Xia,
Hua Xiao,
Chong Han,
Zhibo You,
Junjie Wang,
Fang Cao

Published: July 5, 2024
https://doi.org/10.1371/journal.pone.0305343

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Retinal ganglion cells
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Oxidative stress
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Apoptosis
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Biochemical simulations
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Molecular docking
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DNA-binding proteins
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Drug interactions
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Oxidative damage
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