Blockade of SIRPα-CD47 axis by anti-SIRPα antibody enhances anti-tumor activity of DXd antibody-drug conjugates

• Mayumi Sue,

  Roles Conceptualization, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Discovery Research Laboratories II, Daiichi Sankyo Co., Ltd., Tokyo, Japan

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• Takuya Tsubaki,

  Roles Investigation, Writing – review & editing

  Affiliation Modality Research Laboratories III, Daiichi Sankyo Co., Ltd., Tokyo, Japan

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• Yoko Ishimoto,

  Roles Investigation, Writing – review & editing

  Affiliation Translational Science Department I, Daiichi Sankyo Co., Ltd., Tokyo, Japan

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• Shinko Hayashi,

  Roles Investigation, Writing – review & editing

  Affiliation Discovery Research Laboratories II, Daiichi Sankyo Co., Ltd., Tokyo, Japan

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• Saori Ishida,

  Roles Investigation, Writing – review & editing

  Affiliation Discovery Research Laboratories II, Daiichi Sankyo Co., Ltd., Tokyo, Japan

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• Takafumi Otsuka,

  Roles Investigation, Writing – review & editing

  Affiliation Research Innovation Planning Department, Daiichi Sankyo Co., Ltd., Tokyo, Japan

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• Yoshitaka Isumi,

  Roles Investigation, Writing – review & editing

  Affiliation Discovery Research Laboratories II, Daiichi Sankyo Co., Ltd., Tokyo, Japan

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• Yumi Kawase,

  Roles Investigation, Writing – review & editing

  Affiliation Discovery Research Laboratories V, Daiichi Sankyo Co., Ltd., Tokyo, Japan

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• Junko Yamaguchi,

  Roles Resources, Writing – review & editing

  Affiliation Discovery Research Laboratories I, Daiichi Sankyo Co., Ltd., Tokyo, Japan

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• Takashi Nakada,

  Roles Resources, Writing – review & editing

  Affiliation Modality Research Laboratories I, Daiichi Sankyo Co., Ltd., Tokyo, Japan

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• Jun Ishiguro,

  Roles Investigation, Writing – review & editing

  Affiliation Discovery Research Laboratories V, Daiichi Sankyo Co., Ltd., Tokyo, Japan

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• Kensuke Nakamura,

  Roles Resources, Writing – review & editing

  Affiliation Modality Research Laboratories II, Daiichi Sankyo Co., Ltd., Tokyo, Japan

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• Reimi Kawaida,

  Roles Supervision, Writing – review & editing

  Affiliation Discovery Research Laboratories V, Daiichi Sankyo Co., Ltd., Tokyo, Japan

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• Toshiaki Ohtsuka,

  Roles Conceptualization, Writing – review & editing

  Affiliation Discovery Research Laboratories V, Daiichi Sankyo Co., Ltd., Tokyo, Japan

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• Teiji Wada,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  Affiliation Discovery Research Laboratories II, Daiichi Sankyo Co., Ltd., Tokyo, Japan

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• Toshinori Agatsuma,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation R&D Division, Daiichi Sankyo Co., Ltd., Tokyo, Japan

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•  [ ... ],
• Norihito Kawasaki

  Roles Conceptualization, Investigation, Writing – original draft, Writing – review & editing

  * E-mail: kawasaki.norihito.yt@daiichisankyo.co.jp

  Affiliation Discovery Research Laboratories II, Daiichi Sankyo Co., Ltd., Tokyo, Japan

  https://orcid.org/0009-0000-2375-6562

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