Afatinib or Bevacizumab in combination with Osimertinib efficiently control tumor development in orthotopic murine models of non-small lung cancer

Ulrich Jarry; Megane Bostoen; Jérome Archambeau; Raphaël Pineau; Laura Chaillot; Florence Jouan; Hélène Solhi; Hugo Ferrari; Rémy Le Guevel; Valentine Mennessier; Hervé Lena; Romain Corre; Charles Ricordel; Thierry Guillaudeux; Rémy Pedeux

doi:10.1371/journal.pone.0304914

Loading metrics

Open Access

Peer-reviewed

Research Article

Afatinib or Bevacizumab in combination with Osimertinib efficiently control tumor development in orthotopic murine models of non-small lung cancer

Ulrich Jarry ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: remy.pedeux@univ-rennes.fr (RP); ulrich.jarry@univ-rennes.fr (UJ)

Affiliations Univ Rennes, CNRS, INSERM, BIOSIT UAR 3480, US_S 018, Oncotrial, Rennes, France, Biotrial Pharmacology, Unité de Pharmacologie Préclinique, Rennes, France

https://orcid.org/0000-0001-7961-0378

⨯
Megane Bostoen,

Roles Formal analysis, Investigation

Affiliation Univ Rennes, CNRS, INSERM, BIOSIT UAR 3480, US_S 018, Oncotrial, Rennes, France
⨯
Jérome Archambeau,

Roles Formal analysis, Investigation

Affiliations Univ Rennes, CNRS, INSERM, BIOSIT UAR 3480, US_S 018, Oncotrial, Rennes, France, Univ Rennes, INSERM, OSS (Oncogenesis Stress Signaling), UMR_S 1242, CLCC Eugene Marquis, Rennes, France
⨯
Raphaël Pineau,

Roles Formal analysis, Investigation

Affiliation Univ Rennes, INSERM, OSS (Oncogenesis Stress Signaling), UMR_S 1242, CLCC Eugene Marquis, Rennes, France
⨯
Laura Chaillot,

Roles Formal analysis, Investigation

Affiliations Univ Rennes, CNRS, INSERM, BIOSIT UAR 3480, US_S 018, Oncotrial, Rennes, France, Univ Rennes, INSERM, OSS (Oncogenesis Stress Signaling), UMR_S 1242, CLCC Eugene Marquis, Rennes, France
⨯
Florence Jouan,

Roles Formal analysis, Investigation

Affiliation Univ Rennes, INSERM, OSS (Oncogenesis Stress Signaling), UMR_S 1242, CLCC Eugene Marquis, Rennes, France
⨯
Hélène Solhi,

Roles Formal analysis, Investigation

Affiliation Univ Rennes, CNRS, INSERM, BIOSIT UAR 3480, US_S 018, Oncotrial, Rennes, France
⨯
Hugo Ferrari,

Roles Investigation

Affiliation Univ Rennes, CNRS, INSERM, BIOSIT UAR 3480, US_S 018, Oncotrial, Rennes, France
⨯
Rémy Le Guevel,

Roles Formal analysis, Investigation

Affiliation Univ Rennes, CNRS, INSERM, BIOSIT UAR 3480, US_S 018, Oncotrial, Rennes, France
⨯
Valentine Mennessier,

Roles Formal analysis, Investigation

Affiliation Biotrial Pharmacology, Unité de Pharmacologie Préclinique, Rennes, France
⨯
Hervé Lena,

Roles Conceptualization, Supervision

Affiliations Univ Rennes, INSERM, OSS (Oncogenesis Stress Signaling), UMR_S 1242, CLCC Eugene Marquis, Rennes, France, Centre Hospitalier Universitaire de Rennes, Univ Rennes, Rennes, France
⨯
Romain Corre,

Roles Conceptualization, Supervision

Affiliations Univ Rennes, INSERM, OSS (Oncogenesis Stress Signaling), UMR_S 1242, CLCC Eugene Marquis, Rennes, France, Centre Hospitalier Universitaire de Rennes, Univ Rennes, Rennes, France
⨯
Charles Ricordel,

Roles Conceptualization, Investigation, Supervision

Affiliations Univ Rennes, INSERM, OSS (Oncogenesis Stress Signaling), UMR_S 1242, CLCC Eugene Marquis, Rennes, France, Centre Hospitalier Universitaire de Rennes, Univ Rennes, Rennes, France
⨯
Thierry Guillaudeux,

Roles Conceptualization, Funding acquisition, Supervision

Affiliations Univ Rennes, CNRS, INSERM, BIOSIT UAR 3480, US_S 018, Oncotrial, Rennes, France, Univ Rennes, INSERM, OSS (Oncogenesis Stress Signaling), UMR_S 1242, CLCC Eugene Marquis, Rennes, France
⨯
Rémy Pedeux

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: remy.pedeux@univ-rennes.fr (RP); ulrich.jarry@univ-rennes.fr (UJ)

Affiliations Univ Rennes, CNRS, INSERM, BIOSIT UAR 3480, US_S 018, Oncotrial, Rennes, France, Univ Rennes, INSERM, OSS (Oncogenesis Stress Signaling), UMR_S 1242, CLCC Eugene Marquis, Rennes, France
⨯

Afatinib or Bevacizumab in combination with Osimertinib efficiently control tumor development in orthotopic murine models of non-small lung cancer

Ulrich Jarry,
Megane Bostoen,
Jérome Archambeau,
Raphaël Pineau,
Laura Chaillot,
Florence Jouan,
Hélène Solhi,
Hugo Ferrari,
Rémy Le Guevel,
Valentine Mennessier

Published: June 27, 2024
https://doi.org/10.1371/journal.pone.0304914

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cancers and neoplasms
Is the Subject Area "Cancers and neoplasms" applicable to this article?

Thanks for your feedback.
Non-small cell lung cancer
Is the Subject Area "Non-small cell lung cancer" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Bioluminescence
Is the Subject Area "Bioluminescence" applicable to this article?

Thanks for your feedback.
Lung and intrathoracic tumors
Is the Subject Area "Lung and intrathoracic tumors" applicable to this article?

Thanks for your feedback.
Secondary lung tumors
Is the Subject Area "Secondary lung tumors" applicable to this article?

Thanks for your feedback.
Mice
Is the Subject Area "Mice" applicable to this article?

Thanks for your feedback.
Point mutation
Is the Subject Area "Point mutation" applicable to this article?

Thanks for your feedback.