Platelet-derived microvesicles isolated from type-2 diabetes mellitus patients harbour an altered miRNA signature and drive MDA-MB-231 triple-negative breast cancer cell invasion

Anca Tutuianu; Chinedu A. Anene; Mikayla Shelton; Valerie Speirs; Donald C. Whitelaw; Joanne Thorpe; Wayne Roberts; James R. Boyne

doi:10.1371/journal.pone.0304870

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Open Access

Peer-reviewed

Research Article

Platelet-derived microvesicles isolated from type-2 diabetes mellitus patients harbour an altered miRNA signature and drive MDA-MB-231 triple-negative breast cancer cell invasion

Anca Tutuianu,

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Writing – review & editing

Affiliation School of Applied Sciences, University of Huddersfield, Huddersfield, United Kingdom
⨯
Chinedu A. Anene,

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Writing – review & editing

Affiliation Biomedical Science, School of Health, Leeds Beckett University, Leeds, United Kingdom
⨯
Mikayla Shelton,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Biomedical Science, School of Health, Leeds Beckett University, Leeds, United Kingdom
⨯
Valerie Speirs,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliation Institute of Medical Science, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, Scotland
⨯
Donald C. Whitelaw,

Roles Conceptualization, Funding acquisition, Investigation, Resources, Supervision, Writing – review & editing

Affiliation Department of Diabetes and Endocrinology, Bradford Royal Infirmary, Bradford, United Kingdom
⨯
Joanne Thorpe,

Roles Investigation, Methodology, Project administration, Supervision

Affiliation Department of Diabetes and Endocrinology, Bradford Royal Infirmary, Bradford, United Kingdom
⨯
Wayne Roberts,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – review & editing

Affiliation Biomedical Science, School of Health, Leeds Beckett University, Leeds, United Kingdom
⨯
James R. Boyne

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: j.boyne@leedsbeckett.ac.uk

Affiliation Biomedical Science, School of Health, Leeds Beckett University, Leeds, United Kingdom

https://orcid.org/0000-0003-1219-6453

⨯

Platelet-derived microvesicles isolated from type-2 diabetes mellitus patients harbour an altered miRNA signature and drive MDA-MB-231 triple-negative breast cancer cell invasion

Anca Tutuianu,
Chinedu A. Anene,
Mikayla Shelton,
Valerie Speirs,
Donald C. Whitelaw,
Joanne Thorpe,
Wayne Roberts,
James R. Boyne

Published: June 20, 2024
https://doi.org/10.1371/journal.pone.0304870

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MicroRNAs
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Diabetes mellitus
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Breast cancer
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Platelets
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Type 2 diabetes
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RNA sequencing
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Blood
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RNA analysis
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