Ultrasound combined with urokinase under key-shaped bone window enhances blood clot lysis in an in vitro model of spontaneous intracerebral hemorrhage

Lei Xu; Qiang Yang; Jian Gong; Jia Wang; Weiming Xiong; Liu Liu; Yang Liu; Weiduo Zhou; Chao Sun; Yidan Liang; Yanglingxi Wang; Yi Xiang; Yongbing Deng; Min Cui

doi:10.1371/journal.pone.0304398

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Open Access

Peer-reviewed

Research Article

Ultrasound combined with urokinase under key-shaped bone window enhances blood clot lysis in an in vitro model of spontaneous intracerebral hemorrhage

Lei Xu ,

Contributed equally to this work with: Lei Xu, Qiang Yang

Roles Conceptualization, Investigation, Project administration

Affiliations Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China, Chongqing Key Laboratory of Emergency Medicine, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China

https://orcid.org/0000-0001-5164-9684

⨯
Qiang Yang ,

Contributed equally to this work with: Lei Xu, Qiang Yang

Roles Data curation, Formal analysis, Methodology

Affiliations Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China, Chongqing Key Laboratory of Emergency Medicine, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China
⨯
Jian Gong,

Roles Writing – original draft

Affiliations Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China, Chongqing Key Laboratory of Emergency Medicine, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China
⨯
Jia Wang,

Roles Data curation, Software

Affiliations Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China, Chongqing Key Laboratory of Emergency Medicine, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China
⨯
Weiming Xiong,

Roles Writing – original draft

Affiliations Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China, Chongqing Key Laboratory of Emergency Medicine, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China
⨯
Liu Liu,

Roles Data curation, Software

Affiliations Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China, Chongqing Key Laboratory of Emergency Medicine, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China
⨯
Yang Liu,

Roles Writing – original draft

Affiliations Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China, Chongqing Key Laboratory of Emergency Medicine, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China
⨯
Weiduo Zhou,

Roles Writing – review & editing

Affiliations Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China, Chongqing Key Laboratory of Emergency Medicine, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China
⨯
Chao Sun,

Roles Data curation, Software

Affiliations Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China, Chongqing Key Laboratory of Emergency Medicine, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China
⨯
Yidan Liang,

Roles Writing – review & editing

Affiliations Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China, Chongqing Key Laboratory of Emergency Medicine, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China
⨯
Yanglingxi Wang,

Roles Data curation, Software

Affiliations Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China, Chongqing Key Laboratory of Emergency Medicine, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China
⨯
Yi Xiang,

Roles Writing – review & editing

Affiliations Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China, Chongqing Key Laboratory of Emergency Medicine, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China
⨯
Yongbing Deng,

Roles Supervision

Affiliations Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China, Chongqing Key Laboratory of Emergency Medicine, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China
⨯
Min Cui

Roles Conceptualization, Supervision

* E-mail: tocuimin@foxmail.com

Affiliations Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China, Chongqing Key Laboratory of Emergency Medicine, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, 400010, China

https://orcid.org/0009-0008-5187-9410

⨯

Ultrasound combined with urokinase under key-shaped bone window enhances blood clot lysis in an in vitro model of spontaneous intracerebral hemorrhage

Lei Xu,
Qiang Yang,
Jian Gong,
Jia Wang,
Weiming Xiong,
Liu Liu,
Yang Liu,
Weiduo Zhou,
Chao Sun,
Yidan Liang

Published: May 30, 2024
https://doi.org/10.1371/journal.pone.0304398

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