Reverse causation bias: A simulation study comparing first- and second-line treatments with an overlap of symptoms between treatment indication and studied outcome

• Christian Bjerregård Øland ,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: qbodk@leo-pharma.com

  Affiliation Biostatistics and Pharmacoepidemiology, LEO Pharma A/S, Ballerup, Denmark

  https://orcid.org/0000-0001-8929-1761

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• Lise Skov Ranch,

  Roles Conceptualization, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Biostatistics and Pharmacoepidemiology, LEO Pharma A/S, Ballerup, Denmark

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• Tea Skaaby,

  Roles Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Biostatistics and Pharmacoepidemiology, LEO Pharma A/S, Ballerup, Denmark

  https://orcid.org/0000-0003-0031-5726

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• Thomas Delvin,

  Roles Conceptualization, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Biostatistics and Pharmacoepidemiology, LEO Pharma A/S, Ballerup, Denmark

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• Henny Bang Jakobsen,

  Roles Conceptualization, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Biostatistics and Pharmacoepidemiology, LEO Pharma A/S, Ballerup, Denmark

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• Christian Bressen Pipper

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Biostatistics and Pharmacoepidemiology, LEO Pharma A/S, Ballerup, Denmark

  https://orcid.org/0000-0003-0261-616X

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