Ninjin’yoeito reduces fatigue-like conditions by alleviating inflammation of the brain and skeletal muscles in aging mice

• Shotaro Otsuka ,

  Contributed equally to this work with: Shotaro Otsuka, Ryoma Matsuzaki

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

  * E-mail: maruyama-i@eva.hi-ho.ne.jp (IM); k3360022@kadai.jp, otsuka-shotaro@oita-u.ac.jp (SO)

  Affiliation Faculty of Welfare and Health Science, Oita University, Oita, Japan

  https://orcid.org/0000-0003-3563-2473

  ⨯
• Ryoma Matsuzaki ,

  Contributed equally to this work with: Shotaro Otsuka, Ryoma Matsuzaki

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation Faculty of Medicine, Department of Physical Therapy, School of Health Sciences, Kagoshima University, Kagoshima, Japan

  ⨯
• Shogo Kakimoto,

  Roles Investigation

  Affiliation Faculty of Medicine, Department of Physical Therapy, School of Health Sciences, Kagoshima University, Kagoshima, Japan

  ⨯
• Yuta Tachibe,

  Roles Investigation

  Affiliation Faculty of Medicine, Department of Physical Therapy, School of Health Sciences, Kagoshima University, Kagoshima, Japan

  ⨯
• Takuya Kawatani,

  Roles Investigation

  Affiliation Faculty of Medicine, Department of Physical Therapy, School of Health Sciences, Kagoshima University, Kagoshima, Japan

  ⨯
• Seiya Takada,

  Roles Investigation

  Affiliation Department of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan

  ⨯
• Akira Tani,

  Roles Investigation

  Affiliation Faculty of Medicine, Department of Physical Therapy, School of Health Sciences, Kagoshima University, Kagoshima, Japan

  ⨯
• Kazuki Nakanishi,

  Roles Investigation

  Affiliation Faculty of Medicine, Department of Physical Therapy, School of Health Sciences, Kagoshima University, Kagoshima, Japan

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• Teruki Matsuoka,

  Roles Investigation

  Affiliation Faculty of Medicine, Department of Physical Therapy, School of Health Sciences, Kagoshima University, Kagoshima, Japan

  ⨯
• Yuki Kato,

  Roles Investigation

  Affiliation Faculty of Medicine, Department of Physical Therapy, School of Health Sciences, Kagoshima University, Kagoshima, Japan

  ⨯
• Masaki Inadome,

  Roles Investigation

  Affiliation Faculty of Medicine, Department of Physical Therapy, School of Health Sciences, Kagoshima University, Kagoshima, Japan

  ⨯
• Nao Nojima,

  Roles Investigation

  Affiliation Faculty of Medicine, Department of Physical Therapy, School of Health Sciences, Kagoshima University, Kagoshima, Japan

  ⨯
• Harutoshi Sakakima,

  Roles Writing – review & editing

  Affiliation Faculty of Medicine, Department of Physical Therapy, School of Health Sciences, Kagoshima University, Kagoshima, Japan

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• Keita Mizuno,

  Roles Funding acquisition

  Affiliation Kampo Research & Development Division, Tsumura Kampo Research Laboratories, Tsumura & Co., Ibaraki, Japan

  ⨯
• Yosuke Matsubara,

  Roles Funding acquisition

  Affiliation Kampo Research & Development Division, Tsumura Kampo Research Laboratories, Tsumura & Co., Ibaraki, Japan

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•  [ ... ],
• Ikuro Maruyama

  Roles Conceptualization, Methodology, Writing – review & editing

  * E-mail: maruyama-i@eva.hi-ho.ne.jp (IM); k3360022@kadai.jp, otsuka-shotaro@oita-u.ac.jp (SO)

  Affiliation Department of Laboratory and Vascular Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan

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