Discovery of allosteric regulators with clinical potential to stabilize alpha-L-iduronidase in mucopolysaccharidosis type I

• Elena Cubero,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Gain Therapeutics Sucursal en España, Barcelona Science Park, Barcelona, Spain

  https://orcid.org/0000-0002-2239-6670

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• Ana Ruano,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Gain Therapeutics Sucursal en España, Barcelona Science Park, Barcelona, Spain

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• Aida Delgado,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Gain Therapeutics Sucursal en España, Barcelona Science Park, Barcelona, Spain

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• Xavier Barril,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliations Gain Therapeutics Sucursal en España, Barcelona Science Park, Barcelona, Spain, Facultat de Farmacia, IBUB & IQTC, Universitat de Barcelona, Barcelona, Spain, Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain

  https://orcid.org/0000-0002-0281-1347

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• Sara Morales,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Gain Therapeutics Sucursal en España, Barcelona Science Park, Barcelona, Spain

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• Ana Trapero,

  Roles Formal analysis, Writing – original draft, Writing – review & editing

  Affiliation Gain Therapeutics Sucursal en España, Barcelona Science Park, Barcelona, Spain

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• Lorenzo Leoni,

  Roles Conceptualization, Writing – review & editing

  Current address: Tiventures SA, Lugano, Switzerland

  Affiliation GT Gain Therapeutics SA, Lugano, Switzerland

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• Manolo Bellotto,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  Affiliation GT Gain Therapeutics SA, Lugano, Switzerland

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• Roberto Maj,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliation GT Gain Therapeutics SA, Lugano, Switzerland

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• Beatriz Calvo-Flores Guzmán,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation GT Gain Therapeutics SA, Lugano, Switzerland

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• Natalia Pérez-Carmona,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Gain Therapeutics Sucursal en España, Barcelona Science Park, Barcelona, Spain

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• Ana Maria Garcia-Collazo

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: amgarcia@gaintherapeutics.com

  Affiliation Gain Therapeutics Sucursal en España, Barcelona Science Park, Barcelona, Spain

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