Loss of the yeast transporter Agp2 upregulates the pleiotropic drug-resistant pump Pdr5 and confers resistance to the protein synthesis inhibitor cycloheximide

Yusra Manzoor; Mustapha Aouida; Ramya Ramadoss; Balasubramanian Moovarkumudalvan; Nisar Ahmed; Abdallah Alhaj Sulaiman; Ashima Mohanty; Reem Ali; Borbala Mifsud; Dindial Ramotar

doi:10.1371/journal.pone.0303747

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Open Access

Peer-reviewed

Research Article

Loss of the yeast transporter Agp2 upregulates the pleiotropic drug-resistant pump Pdr5 and confers resistance to the protein synthesis inhibitor cycloheximide

Yusra Manzoor ,

Contributed equally to this work with: Yusra Manzoor, Mustapha Aouida

Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

Affiliation Division of Biological and Biomedical Sciences, College of Health and Life Sciences, Hamad Bin Khalifa University, Education City, Qatar Foundation, Doha, Qatar

https://orcid.org/0009-0007-8997-5275

⨯
Mustapha Aouida ,

Contributed equally to this work with: Yusra Manzoor, Mustapha Aouida

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Validation, Visualization, Writing – review & editing

Affiliation Division of Biological and Biomedical Sciences, College of Health and Life Sciences, Hamad Bin Khalifa University, Education City, Qatar Foundation, Doha, Qatar

https://orcid.org/0000-0001-7945-5320

⨯
Ramya Ramadoss,

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – review & editing

Affiliation Mahatma Gandhi Medical Advanced Research Institute (MGMARI), Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, India

https://orcid.org/0000-0002-3144-4080

⨯
Balasubramanian Moovarkumudalvan,

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – review & editing

Affiliations Mahatma Gandhi Medical Advanced Research Institute (MGMARI), Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, India, Division of Genomics and Precision Medicine, College of Health and Life Sciences, Hamad Bin Khalifa University, Education City, Qatar Foundation, Doha, Qatar

https://orcid.org/0000-0003-1140-883X

⨯
Nisar Ahmed,

Roles Formal analysis, Methodology, Software, Validation, Visualization, Writing – review & editing

Affiliation Division of Genomics and Precision Medicine, College of Health and Life Sciences, Hamad Bin Khalifa University, Education City, Qatar Foundation, Doha, Qatar
⨯
Abdallah Alhaj Sulaiman,

Roles Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – review & editing

Affiliation Division of Biological and Biomedical Sciences, College of Health and Life Sciences, Hamad Bin Khalifa University, Education City, Qatar Foundation, Doha, Qatar

https://orcid.org/0000-0002-6720-9269

⨯
Ashima Mohanty,

Roles Formal analysis, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Division of Genomics and Precision Medicine, College of Health and Life Sciences, Hamad Bin Khalifa University, Education City, Qatar Foundation, Doha, Qatar

https://orcid.org/0000-0001-6375-2566

⨯
Reem Ali,

Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Division of Biological and Biomedical Sciences, College of Health and Life Sciences, Hamad Bin Khalifa University, Education City, Qatar Foundation, Doha, Qatar
⨯
Borbala Mifsud,

Roles Formal analysis, Funding acquisition, Supervision, Validation, Visualization, Writing – review & editing

Affiliation Division of Genomics and Precision Medicine, College of Health and Life Sciences, Hamad Bin Khalifa University, Education City, Qatar Foundation, Doha, Qatar
⨯
Dindial Ramotar

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: dramotar@hbku.edu.qa

Affiliation Division of Biological and Biomedical Sciences, College of Health and Life Sciences, Hamad Bin Khalifa University, Education City, Qatar Foundation, Doha, Qatar

https://orcid.org/0000-0002-9572-7223

⨯

Loss of the yeast transporter Agp2 upregulates the pleiotropic drug-resistant pump Pdr5 and confers resistance to the protein synthesis inhibitor cycloheximide

Yusra Manzoor,
Mustapha Aouida,
Ramya Ramadoss,
Balasubramanian Moovarkumudalvan,
Nisar Ahmed,
Abdallah Alhaj Sulaiman,
Ashima Mohanty,
Reem Ali,
Borbala Mifsud,
Dindial Ramotar

Published: May 22, 2024
https://doi.org/10.1371/journal.pone.0303747

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Mitochondria
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Gene expression
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Membrane proteins
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Yeast
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