Malic enzyme 1 knockout has no deleterious phenotype and is favored in the male germline under standard laboratory conditions

• Jonathan M. Alektiar ,

  Contributed equally to this work with: Jonathan M. Alektiar, Mengrou Shan

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America

  https://orcid.org/0000-0002-3343-0993

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• Mengrou Shan ,

  Contributed equally to this work with: Jonathan M. Alektiar, Mengrou Shan

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Megan D. Radyk,

  Roles Investigation, Methodology, Project administration

  Affiliation Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Li Zhang,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America

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• Christopher J. Halbrook,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America

  https://orcid.org/0000-0002-3376-3114

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• Lin Lin,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Carlos Espinoza,

  Roles Investigation, Methodology

  Affiliation Department of Surgery, University of Michigan, Ann Arbor, Michigan, United States of America

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• Ivan F. Mier,

  Roles Data curation, Investigation, Methodology

  Affiliation Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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• Brooke L. Lavoie,

  Roles Investigation

  Affiliation Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America

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• Lucie Salvatore,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America

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• Marina Pasca di Magliano,

  Roles Project administration, Supervision

  Affiliations Department of Surgery, University of Michigan, Ann Arbor, Michigan, United States of America, Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America

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• Lewis C. Cantley,

  Roles Conceptualization, Project administration, Resources, Supervision, Writing – review & editing

  Affiliations Department of Cancer Biology, Dana Farber Cancer Center, Boston, Massachusetts, United States of America, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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• Jacob L. Mueller,

  Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Writing – review & editing

  Affiliation Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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• Costas A. Lyssiotis

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: clyssiot@med.umich.edu

  Affiliations Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America, Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America, Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

  https://orcid.org/0000-0001-9309-6141

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