Echinatin attenuates acute lung injury and inflammatory responses via TAK1-MAPK/NF-κB and Keap1-Nrf2-HO-1 signaling pathways in macrophages

Liuling Luo; Huan Wang; Jinrui Xiong; Xiaorui Chen; Xiaofei Shen; Hai Zhang

doi:10.1371/journal.pone.0303556

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Open Access

Peer-reviewed

Research Article

Echinatin attenuates acute lung injury and inflammatory responses via TAK1-MAPK/NF-κB and Keap1-Nrf2-HO-1 signaling pathways in macrophages

Liuling Luo,

Roles Conceptualization, Data curation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

Affiliation State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy/School of Modern Chinese Medicine Industry, Chengdu University of Traditional Chinese Medicine, Chengdu, China
⨯
Huan Wang,

Roles Formal analysis, Methodology, Validation, Writing – original draft

Affiliation State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy/School of Modern Chinese Medicine Industry, Chengdu University of Traditional Chinese Medicine, Chengdu, China
⨯
Jinrui Xiong,

Roles Formal analysis, Writing – original draft

Affiliation State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy/School of Modern Chinese Medicine Industry, Chengdu University of Traditional Chinese Medicine, Chengdu, China
⨯
Xiaorui Chen ,

Roles Investigation, Supervision

* E-mail: 154369580@qq.com (XC); sxfcd2008@163.com (XS); zhanghai@cdutcm.edu.cn (HZ)

Affiliation State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy/School of Modern Chinese Medicine Industry, Chengdu University of Traditional Chinese Medicine, Chengdu, China
⨯
Xiaofei Shen ,

Roles Conceptualization, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: 154369580@qq.com (XC); sxfcd2008@163.com (XS); zhanghai@cdutcm.edu.cn (HZ)

Affiliation Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China
⨯
Hai Zhang

Roles Data curation, Funding acquisition, Resources

* E-mail: 154369580@qq.com (XC); sxfcd2008@163.com (XS); zhanghai@cdutcm.edu.cn (HZ)

Affiliation State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy/School of Modern Chinese Medicine Industry, Chengdu University of Traditional Chinese Medicine, Chengdu, China

https://orcid.org/0000-0001-6775-1050

⨯

Echinatin attenuates acute lung injury and inflammatory responses via TAK1-MAPK/NF-κB and Keap1-Nrf2-HO-1 signaling pathways in macrophages

Liuling Luo,
Huan Wang,
Jinrui Xiong,
Xiaorui Chen,
Xiaofei Shen,
Hai Zhang

Published: May 16, 2024
https://doi.org/10.1371/journal.pone.0303556

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