A study protocol to characterise pathophysiological and molecular markers of rheumatic heart disease and degenerative aortic stenosis using multiparametric cardiovascular imaging and multiomics techniques

• Daniel W. Mutithu,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliations Department of Medicine, Cape Heart Institute, University of Cape Town, Cape Town, South Africa, Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa, Extramural Unit on Intersection of Noncommunicable Diseases and Infectious Diseases, South African Medical Research Council, Cape Town, South Africa

  https://orcid.org/0000-0001-8587-0416

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• Olukayode O. Aremu,

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliations Department of Medicine, Cape Heart Institute, University of Cape Town, Cape Town, South Africa, Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa, Extramural Unit on Intersection of Noncommunicable Diseases and Infectious Diseases, South African Medical Research Council, Cape Town, South Africa

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• Dipolelo Mokaila,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliations Department of Medicine, Cape Heart Institute, University of Cape Town, Cape Town, South Africa, Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa, Extramural Unit on Intersection of Noncommunicable Diseases and Infectious Diseases, South African Medical Research Council, Cape Town, South Africa

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• Tasnim Bana,

  Roles Data curation, Investigation, Validation, Writing – review & editing

  Affiliations Department of Medicine, Cape Heart Institute, University of Cape Town, Cape Town, South Africa, Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa, Extramural Unit on Intersection of Noncommunicable Diseases and Infectious Diseases, South African Medical Research Council, Cape Town, South Africa

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• Mary Familusi,

  Roles Investigation, Writing – review & editing

  Affiliations Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa, Department of Civil Engineering, University of Cape Town, Cape Town, South Africa

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• Laura Taylor,

  Roles Data curation, Investigation, Supervision, Writing – review & editing

  Affiliation Division of Forensic Medicine and Toxicology, Department of Pathology, University of Cape Town, Cape Town, South Africa

  https://orcid.org/0000-0002-0936-7314

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• Lorna J. Martin,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Division of Forensic Medicine and Toxicology, Department of Pathology, University of Cape Town, Cape Town, South Africa

  https://orcid.org/0000-0002-1231-7932

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• Laura J. Heathfield,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation Division of Forensic Medicine and Toxicology, Department of Pathology, University of Cape Town, Cape Town, South Africa

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• Jennifer A. Kirwan,

  Roles Data curation, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliations Metabolomics Platform, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany, Max-Delbrück-Center (MDC) for Molecular Medicine, Helmholtz Association, Berlin, Germany

  https://orcid.org/0000-0002-5423-1651

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• Lubbe Wiesner,

  Roles Data curation, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

  https://orcid.org/0000-0002-9070-8699

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• Henry A. Adeola,

  Roles Data curation, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Division of Dermatology, Department of Medicine, University of Cape Town, Cape Town, South Africa

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• Evelyn N. Lumngwena,

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliations Department of Medicine, Cape Heart Institute, University of Cape Town, Cape Town, South Africa, Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa, Extramural Unit on Intersection of Noncommunicable Diseases and Infectious Diseases, South African Medical Research Council, Cape Town, South Africa, School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South Africa

  https://orcid.org/0000-0002-9302-8218

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• Rodgers Manganyi,

  Roles Investigation, Writing – review & editing

  Affiliation Chris Barnard Division of Cardiothoracic Surgery, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa

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• Sebastian Skatulla,

  Roles Conceptualization, Data curation, Funding acquisition, Methodology, Supervision, Writing – review & editing

  Affiliation Department of Civil Engineering, University of Cape Town, Cape Town, South Africa

  https://orcid.org/0000-0003-1061-3356

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• Richard Naidoo,

  Roles Data curation, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Division of Anatomical Pathology, Department of Pathology, University of Cape Town and National Health Laboratory Service, Cape Town, South Africa

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•  [ ... ],
• Ntobeko A. B. Ntusi

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

  * E-mail: ntobeko.ntusi@uct.ac.za

  Affiliations Department of Medicine, Cape Heart Institute, University of Cape Town, Cape Town, South Africa, Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa, Extramural Unit on Intersection of Noncommunicable Diseases and Infectious Diseases, South African Medical Research Council, Cape Town, South Africa, Cape Universities Body Imaging Centre, University of Cape Town, Cape Town, South Africa, Wellcome Centre for Infectious Disease Research, University of Cape Town, Cape Town, South Africa

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