Sphingosine-1-phosphate promotes liver fibrosis in metabolic dysfunction-associated steatohepatitis

• Yosuke Osawa ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Supervision, Writing – original draft

  * E-mail: osawa-gif@umin.ac.jp

  Affiliations Departments of Gastroenterology, International University of Health and Welfare Hospital, Tochigi, Japan, Department of Liver Diseases, The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Chiba, Japan

  https://orcid.org/0000-0003-3581-1009

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• Hironari Kawai,

  Roles Investigation

  Affiliations Department of Liver Diseases, The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Chiba, Japan, Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan

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• Keigo Nakashima,

  Roles Resources

  Affiliations Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan, Departments of Surgery, International University of Health and Welfare Hospital, Tochigi, Japan

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• Yuichi Nakaseko,

  Roles Resources

  Affiliations Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan, Departments of Surgery, International University of Health and Welfare Hospital, Tochigi, Japan

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• Daisuke Suto,

  Roles Resources

  Affiliation Departments of Gastroenterology, International University of Health and Welfare Hospital, Tochigi, Japan

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• Keisuke Yanagida,

  Roles Investigation

  Affiliation Departments of Lipid Life Science, National Center for Global Health and Medicine, Tokyo, Japan

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• Tomomi Hashidate-Yoshida,

  Roles Investigation

  Affiliation Departments of Lipid Life Science, National Center for Global Health and Medicine, Tokyo, Japan

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• Taizo Mori,

  Roles Investigation

  Affiliation Department of Liver Diseases, The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Chiba, Japan

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• Sachiyo Yoshio,

  Roles Investigation

  Affiliation Department of Liver Diseases, The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Chiba, Japan

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• Takaaki Ohtake,

  Roles Resources

  Affiliation Departments of Gastroenterology, International University of Health and Welfare Hospital, Tochigi, Japan

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• Hideo Shindou,

  Roles Data curation, Funding acquisition, Supervision

  Affiliations Departments of Lipid Life Science, National Center for Global Health and Medicine, Tokyo, Japan, Departments of Medical Lipid Science, Graduated Scholl of Medicine, The University of Tokyo, Tokyo, Japan

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• Tatsuya Kanto

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  Affiliation Department of Liver Diseases, The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Chiba, Japan

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