A polygenic risk score for the QT interval is an independent predictor of drug-induced QT prolongation

• Steven T. Simon,

  Roles Conceptualization, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, United States of America

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• Meng Lin,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

  Affiliation Colorado Center for Personalized Medicine, University of Colorado School of Medicine, Aurora, CO, United States of America

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• Katy E. Trinkley,

  Roles Conceptualization, Methodology, Validation, Writing – review & editing

  Affiliation Department of Clinical Pharmacy, School of Pharmacy, University of Colorado, Aurora, CO, United States of America

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• Ryan Aleong,

  Roles Conceptualization, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, United States of America

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• Nicholas Rafaels,

  Roles Conceptualization, Data curation, Investigation, Resources, Software, Writing – review & editing

  Affiliation Colorado Center for Personalized Medicine, University of Colorado School of Medicine, Aurora, CO, United States of America

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• Kristy R. Crooks,

  Roles Data curation, Methodology, Project administration, Resources, Validation, Writing – review & editing

  Affiliation Colorado Center for Personalized Medicine, University of Colorado School of Medicine, Aurora, CO, United States of America

  https://orcid.org/0000-0001-8263-096X

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• Michael J. Reiter,

  Roles Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, United States of America

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• Christopher R. Gignoux,

  Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Colorado Center for Personalized Medicine, University of Colorado School of Medicine, Aurora, CO, United States of America

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• Michael A. Rosenberg

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: michael.a.rosenberg@cuanschutz.edu

  Affiliation Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, United States of America

  https://orcid.org/0000-0002-6708-1648

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