Refining the rheological characteristics of high drug loading ointment via SDS and machine learning

Xilong Qian; Kewei Wang; Yulu Ma; Fang Fang; Xiangsong Meng; Liu Zhou; Yanqiong Pan; Yang Zhang; Yehuang Wang; Xiuxiu Wang; Jing Zhao; Bin Jiang; Shengjin Liu

doi:10.1371/journal.pone.0303199

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Open Access

Peer-reviewed

Research Article

Refining the rheological characteristics of high drug loading ointment via SDS and machine learning

Xilong Qian ,

Contributed equally to this work with: Xilong Qian, Kewei Wang

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine, Nanjing, China, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing, China, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
⨯
Kewei Wang ,

Contributed equally to this work with: Xilong Qian, Kewei Wang

Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, China
⨯
Yulu Ma,

Roles Data curation, Investigation, Methodology, Project administration, Validation, Visualization, Writing – review & editing

Affiliations State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine, Nanjing, China, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
⨯
Fang Fang,

Roles Methodology, Project administration, Validation

Affiliations State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine, Nanjing, China, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
⨯
Xiangsong Meng,

Roles Methodology, Validation

Affiliation Bozhou University, Bozhou, China
⨯
Liu Zhou,

Roles Data curation, Validation

Affiliations State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine, Nanjing, China, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing, China, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
⨯
Yanqiong Pan,

Roles Data curation

Affiliations State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine, Nanjing, China, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing, China, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China, Taikang Xianlin Drum Tower Hospital, Nanjing, China
⨯
Yang Zhang ,

Roles Formal analysis, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: lsj@njucm.edu.cn (SL); Zhangyang1@medmail.com.cn (YZ)

Affiliation Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, China
⨯
Yehuang Wang,

Roles Formal analysis

Affiliation Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, China
⨯
Xiuxiu Wang,

Roles Formal analysis, Writing – original draft

Affiliation Chemistry and Biomedicine Innovation Center (Chem BIC), School of Chemistry and Chemical Engineering Nanjing University, Nanjing, China
⨯
Jing Zhao,

Roles Formal analysis, Writing – review & editing

Affiliation Chemistry and Biomedicine Innovation Center (Chem BIC), School of Chemistry and Chemical Engineering Nanjing University, Nanjing, China
⨯
Bin Jiang,

Roles Formal analysis, Writing – review & editing

Affiliation Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, China
⨯
Shengjin Liu

Roles Formal analysis, Validation, Writing – original draft, Writing – review & editing

* E-mail: lsj@njucm.edu.cn (SL); Zhangyang1@medmail.com.cn (YZ)

Affiliations State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine, Nanjing, China, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing, China, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China

https://orcid.org/0000-0003-4404-1464

⨯

Refining the rheological characteristics of high drug loading ointment via SDS and machine learning

Xilong Qian,
Kewei Wang,
Yulu Ma,
Fang Fang,
Xiangsong Meng,
Liu Zhou,
Yanqiong Pan,
Yang Zhang,
Yehuang Wang,
Xiuxiu Wang

Published: May 9, 2024
https://doi.org/10.1371/journal.pone.0303199

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