Persistent and robust antibody responses to ChAdOx1-S Oxford-AstraZeneca (ChAdOx1-S, Covishield) SARS-CoV-2 vaccine observed in Ugandans across varied baseline immune profiles

Jennifer Serwanga; Gerald Kevin Oluka; Claire Baine; Violet Ankunda; Jackson Sembera; Laban Kato; Joseph Ssebwana Katende; Geoffrey Odoch; Betty Oliver Auma; Ben Gombe; The COVID-19 Immunoprofiling Team; Monica Musenero; Pontiano Kaleebu

doi:10.1371/journal.pone.0303113

Loading metrics

Open Access

Peer-reviewed

Research Article

Persistent and robust antibody responses to ChAdOx1-S Oxford-AstraZeneca (ChAdOx1-S, Covishield) SARS-CoV-2 vaccine observed in Ugandans across varied baseline immune profiles

Jennifer Serwanga ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: Jennifer.Serwanga@mrcuganda.org

Affiliations Viral Pathogens Theme, MRC/UVRI & London School of Hygiene and Tropical Medicine, Uganda Research Unit, Entebbe, Uganda, Department of Immunology, Uganda Virus Research Institute, Entebbe, Uganda
⨯
Gerald Kevin Oluka,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliations Viral Pathogens Theme, MRC/UVRI & London School of Hygiene and Tropical Medicine, Uganda Research Unit, Entebbe, Uganda, Department of Immunology, Uganda Virus Research Institute, Entebbe, Uganda
⨯
Claire Baine,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Immunology, Uganda Virus Research Institute, Entebbe, Uganda

https://orcid.org/0009-0003-6442-2253

⨯
Violet Ankunda,

Roles Data curation, Formal analysis, Methodology, Validation, Visualization

Affiliation Department of Immunology, Uganda Virus Research Institute, Entebbe, Uganda
⨯
Jackson Sembera,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Department of Immunology, Uganda Virus Research Institute, Entebbe, Uganda
⨯
Laban Kato,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Viral Pathogens Theme, MRC/UVRI & London School of Hygiene and Tropical Medicine, Uganda Research Unit, Entebbe, Uganda
⨯
Joseph Ssebwana Katende,

Roles Conceptualization, Investigation, Methodology, Writing – review & editing

Affiliations Viral Pathogens Theme, MRC/UVRI & London School of Hygiene and Tropical Medicine, Uganda Research Unit, Entebbe, Uganda, Department of Immunology, Uganda Virus Research Institute, Entebbe, Uganda

https://orcid.org/0000-0002-6540-5522

⨯
Geoffrey Odoch,

Roles Investigation, Methodology, Writing – review & editing

Affiliations Viral Pathogens Theme, MRC/UVRI & London School of Hygiene and Tropical Medicine, Uganda Research Unit, Entebbe, Uganda, Department of Immunology, Uganda Virus Research Institute, Entebbe, Uganda
⨯
Betty Oliver Auma,

Roles Data curation, Investigation, Methodology, Project administration, Writing – review & editing

Affiliations Viral Pathogens Theme, MRC/UVRI & London School of Hygiene and Tropical Medicine, Uganda Research Unit, Entebbe, Uganda, Department of Immunology, Uganda Virus Research Institute, Entebbe, Uganda
⨯
Ben Gombe,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Viral Pathogens Theme, MRC/UVRI & London School of Hygiene and Tropical Medicine, Uganda Research Unit, Entebbe, Uganda
⨯
The COVID-19 Immunoprofiling Team,

Roles Investigation, Methodology, Writing – review & editing

Affiliations Viral Pathogens Theme, MRC/UVRI & London School of Hygiene and Tropical Medicine, Uganda Research Unit, Entebbe, Uganda, Department of Immunology, Uganda Virus Research Institute, Entebbe, Uganda
⨯
Monica Musenero,

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation Science, Technology, and Innovation Secretariat, Office of the President, Government of Uganda, Kampala, Uganda
⨯
Pontiano Kaleebu

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Viral Pathogens Theme, MRC/UVRI & London School of Hygiene and Tropical Medicine, Uganda Research Unit, Entebbe, Uganda, Department of Immunology, Uganda Virus Research Institute, Entebbe, Uganda
⨯

Persistent and robust antibody responses to ChAdOx1-S Oxford-AstraZeneca (ChAdOx1-S, Covishield) SARS-CoV-2 vaccine observed in Ugandans across varied baseline immune profiles

Jennifer Serwanga,
Gerald Kevin Oluka,
Claire Baine,
Violet Ankunda,
Jackson Sembera,
Laban Kato,
Joseph Ssebwana Katende,
Geoffrey Odoch,
Betty Oliver Auma,
Ben Gombe

Published: July 29, 2024
https://doi.org/10.1371/journal.pone.0303113

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Antibodies
Is the Subject Area "Antibodies" applicable to this article?

Thanks for your feedback.
Antibody response
Is the Subject Area "Antibody response" applicable to this article?

Thanks for your feedback.
Immune response
Is the Subject Area "Immune response" applicable to this article?

Thanks for your feedback.
Vaccination and immunization
Is the Subject Area "Vaccination and immunization" applicable to this article?

Thanks for your feedback.
Booster doses
Is the Subject Area "Booster doses" applicable to this article?

Thanks for your feedback.
Enzyme-linked immunoassays
Is the Subject Area "Enzyme-linked immunoassays" applicable to this article?

Thanks for your feedback.
SARS CoV 2
Is the Subject Area "SARS CoV 2" applicable to this article?

Thanks for your feedback.
Viral vaccines
Is the Subject Area "Viral vaccines" applicable to this article?

Thanks for your feedback.