Mutation of SIVA, a candidate metastasis gene identified from clonally related bilateral breast cancers, promotes breast cancer cell spread in vitro and in vivo

• Anke Vermehren-Schmaedick ,

  Contributed equally to this work with: Anke Vermehren-Schmaedick, Myron Peto

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliations Veterans Administration Portland Health Care System, Portland, Oregon, United States of America, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States of America, Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, Oregon, United States of America

  https://orcid.org/0000-0003-3788-1406

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• Myron Peto ,

  Contributed equally to this work with: Anke Vermehren-Schmaedick, Myron Peto

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States of America

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• Wendy Wagoner,

  Roles Investigation

  Affiliations Veterans Administration Portland Health Care System, Portland, Oregon, United States of America, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States of America, Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, Oregon, United States of America

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• Kami E. Chiotti,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon, United States of America

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• Elizabeth Ramsey,

  Roles Data curation, Investigation

  Affiliations Veterans Administration Portland Health Care System, Portland, Oregon, United States of America, Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, Oregon, United States of America

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• Xiaoyan Wang,

  Roles Investigation

  Affiliation Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon, United States of America

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• Shauna Rakshe,

  Roles Formal analysis, Writing – review & editing

  Affiliation Knight Cancer Institute, Biostatistics Shared Resource, Oregon Health & Science University, Portland, Oregon, United States of America

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• Jessica Minnier,

  Roles Formal analysis, Writing – review & editing

  Affiliation Knight Cancer Institute, Biostatistics Shared Resource, Oregon Health & Science University, Portland, Oregon, United States of America

  https://orcid.org/0000-0002-3527-2757

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• Rosalie Sears,

  Roles Methodology, Writing – review & editing

  Affiliations Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States of America, Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon, United States of America, Brenden-Colson Center for Pancreatic Care, School of Medicine, Oregon Health & Science University, Portland, Oregon, United States of America

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• Paul Spellman ,

  Roles Conceptualization, Formal analysis, Supervision, Validation, Writing – review & editing

  ¶‡ PS and S-WL are contributed with Equal supervision

  Affiliations Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States of America, University of California Los Angeles, Los Angeles, California, United States of America

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• Shiuh-Wen Luoh

  Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: luohs@ohsu.edu, shiuh-wen.luoh@va.gov

  ¶‡ PS and S-WL are contributed with Equal supervision

  Affiliations Veterans Administration Portland Health Care System, Portland, Oregon, United States of America, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States of America, Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, Oregon, United States of America

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