Integrating bulk and single-cell RNA sequencing reveals SH3D21 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway

Wangxia Tong; Na Qin; Tao Lu; Li Liu; Rong Liu; Jibing Chen; Ning Luo

doi:10.1371/journal.pone.0302766

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Open Access

Peer-reviewed

Research Article

Integrating bulk and single-cell RNA sequencing reveals SH3D21 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway

Wangxia Tong ,

Contributed equally to this work with: Wangxia Tong, Na Qin

Roles Data curation, Methodology, Resources

Affiliation Department of Hepatology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, China
⨯
Na Qin ,

Contributed equally to this work with: Wangxia Tong, Na Qin

Roles Data curation, Methodology

Affiliation The Graduate School of Guangxi University of Chinese Medicine, Nanning, Guangxi, China
⨯
Tao Lu,

Roles Data curation, Methodology

Affiliation Department of hepatobiliary surgery, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, China
⨯
Li Liu,

Roles Formal analysis, Methodology

Affiliation Department of Hepatology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, China
⨯
Rong Liu,

Roles Methodology

Affiliation Department of Hepatology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, China
⨯
Jibing Chen ,

Roles Formal analysis, Resources, Supervision, Validation

* E-mail: jibingchen398@163.com (JC); ln760320@163.com (NL)

¶‡ JC and NL also contributed equally to this work.

Affiliation Centre for Translational Medical Research in Integrative Chinese and Western Medicine, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, China
⨯
Ning Luo

Roles Conceptualization, Resources, Writing – review & editing

* E-mail: jibingchen398@163.com (JC); ln760320@163.com (NL)

¶‡ JC and NL also contributed equally to this work.

Affiliation Department of Neurology, RuiKang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, China

https://orcid.org/0000-0002-3892-524X

⨯

Integrating bulk and single-cell RNA sequencing reveals SH3D21 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway

Wangxia Tong,
Na Qin,
Tao Lu,
Li Liu,
Rong Liu,
Jibing Chen,
Ning Luo

Published: April 3, 2025
https://doi.org/10.1371/journal.pone.0302766

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