Energy landscape analysis and time-series clustering analysis of patient state multistability related to rheumatoid arthritis drug treatment: The KURAMA cohort study

• Keiichi Yamamoto ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: yamamoto-k@cc.osaka-dent.ac.jp

  Affiliation Division of Data Science, Center for Industrial Research and Innovation, Translational Research Institute for Medical Innovation, Osaka Dental University, Hirakata City, Osaka, Japan

  https://orcid.org/0000-0003-3278-5001

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• Masahiko Sakaguchi,

  Roles Conceptualization, Formal analysis, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Engineering Informatics, Faculty of Information and Communication Engineering, Osaka Electro-Communication University, Neyagawa City, Osaka, Japan

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• Akira Onishi,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Department of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, Japan

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• Shinichiro Yokoyama,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Validation, Visualization, Writing – review & editing

  Affiliation Oracle, Tokyo, Japan

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• Yusuke Matsui,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Validation, Visualization, Writing – review & editing

  Affiliation Oracle, Tokyo, Japan

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• Wataru Yamamoto,

  Roles Conceptualization, Data curation, Investigation, Methodology, Validation, Writing – review & editing

  Affiliations Department of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, Japan, Department of Health Information Management, Kurashiki Sweet Hospital, Nakasho, Kurashiki, Kurashiki City, Okayama Prefecture, Japan

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• Hideo Onizawa,

  Roles Data curation, Investigation, Validation, Writing – review & editing

  Affiliation Department of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, Japan

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• Takayuki Fujii,

  Roles Data curation, Investigation, Validation, Writing – review & editing

  Affiliation Department of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, Japan

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• Koichi Murata,

  Roles Data curation, Investigation, Validation, Writing – review & editing

  Affiliation Department of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, Japan

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• Masao Tanaka,

  Roles Data curation, Investigation, Validation, Writing – review & editing

  Affiliation Department of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, Japan

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• Motomu Hashimoto,

  Roles Conceptualization, Investigation, Methodology, Supervision, Validation, Writing – review & editing

  Affiliation Department of Clinical Immunology, Osaka Metropolitan University Graduate School of Medicine, Osaka City, Japan

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• Shuichi Matsuda,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliation Department of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, Japan

  https://orcid.org/0000-0003-0802-1255

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• Akio Morinobu

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliation Department of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, Japan

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