Activated NAD⁺ biosynthesis pathway induces olaparib resistance in BRCA1 knockout pancreatic cancer cells

• Yuka Sasaki ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Validation, Writing – original draft, Writing – review & editing

  * E-mail: sasaki-y@cc.osaka-dent.ac.jp

  Affiliations Department of Pharmacology, Faculty of Dentistry, Osaka Dental University, Hirakata, Osaka, Japan, Department of Molecular and Genomic Biomedicine, Center for Bioinformatics and Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan

  https://orcid.org/0000-0001-5841-1898

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• Takuma Inouchi,

  Roles Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliation Department of Pharmacology, Faculty of Dentistry, Osaka Dental University, Hirakata, Osaka, Japan

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• Ryusuke Nakatsuka,

  Roles Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliation Department of Pharmacology, Faculty of Dentistry, Osaka Dental University, Hirakata, Osaka, Japan

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• Amane Inoue,

  Roles Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliation Department of Pharmacology, Faculty of Dentistry, Osaka Dental University, Hirakata, Osaka, Japan

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• Mitsuko Masutani,

  Roles Conceptualization, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Molecular and Genomic Biomedicine, Center for Bioinformatics and Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan

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• Tadashige Nozaki

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Pharmacology, Faculty of Dentistry, Osaka Dental University, Hirakata, Osaka, Japan

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