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Open Access
Peer-reviewed
Research Article
The efficacy of ferroptosis-inducing compounds IKE and RSL3 correlates with the expression of ferroptotic pathway regulators CD71 and SLC7A11 in biliary tract cancer cells
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Dino Bekric ,
Roles Conceptualization, Data curation, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing
* E-mail: christian.mayr@pmu.ac.at (CM); dino.bekric@pmu.ac.at (DB)
Affiliations Center of Physiology, Pathophysiology and Biophysics, Institute of Physiology and Pathophysiology Salzburg, Paracelsus Medical University, Salzburg, Austria, Cancer Cluster Salzburg, Salzburg, Austria
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Tobias Kiesslich,
Roles Conceptualization, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliations Center of Physiology, Pathophysiology and Biophysics, Institute of Physiology and Pathophysiology Salzburg, Paracelsus Medical University, Salzburg, Austria, Department of Internal Medicine I, University Clinics Salzburg, Paracelsus Medical University, Salzburg, Austria
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Matthias Ocker,
Roles Methodology, Project administration, Writing – review & editing
Affiliations Division of Hematology, Oncology, and Cancer Immunology, Medical Department, Charité University Medicine Berlin, Berlin, Germany, Tacalyx GmbH, Berlin, Germany
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Martina Winklmayr,
Roles Investigation, Methodology, Writing – review & editing
Affiliation Ludwig Boltzmann Institute for Arthritis und Rehabilitation, Paracelsus Medical University, Salzburg, Austria
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Markus Ritter,
Roles Supervision, Validation, Writing – review & editing
Affiliations Center of Physiology, Pathophysiology and Biophysics, Institute of Physiology and Pathophysiology Salzburg, Paracelsus Medical University, Salzburg, Austria, Ludwig Boltzmann Institute for Arthritis und Rehabilitation, Paracelsus Medical University, Salzburg, Austria, Gastein Research Institute, Paracelsus Medical University, Salzburg, Austria, Kathmandu Medical School of Medical Sciences, Dhulikhel, Nepal
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Heidemarie Dobias,
Roles Formal analysis, Writing – review & editing
Affiliation Center of Physiology, Pathophysiology and Biophysics, Institute of Physiology and Pathophysiology Salzburg, Paracelsus Medical University, Salzburg, Austria
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Marlena Beyreis,
Roles Formal analysis, Software, Visualization, Writing – review & editing
Affiliation Center of Physiology, Pathophysiology and Biophysics, Institute of Physiology and Pathophysiology Salzburg, Paracelsus Medical University, Salzburg, Austria
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Daniel Neureiter,
Roles Investigation, Supervision, Validation, Writing – original draft, Writing – review & editing
Affiliations Cancer Cluster Salzburg, Salzburg, Austria, Institute of Pathology, University Clinics Salzburg, Paracelsus Medical University, Salzburg, Austria
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Christian Mayr
Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing
* E-mail: christian.mayr@pmu.ac.at (CM); dino.bekric@pmu.ac.at (DB)
Affiliations Center of Physiology, Pathophysiology and Biophysics, Institute of Physiology and Pathophysiology Salzburg, Paracelsus Medical University, Salzburg, Austria, Department of Internal Medicine I, University Clinics Salzburg, Paracelsus Medical University, Salzburg, Austria
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The efficacy of ferroptosis-inducing compounds IKE and RSL3 correlates with the expression of ferroptotic pathway regulators CD71 and SLC7A11 in biliary tract cancer cells
- Dino Bekric,
- Tobias Kiesslich,
- Matthias Ocker,
- Martina Winklmayr,
- Markus Ritter,
- Heidemarie Dobias,
- Marlena Beyreis,
- Daniel Neureiter,
- Christian Mayr
- Published: April 11, 2024
- https://doi.org/10.1371/journal.pone.0302050