A comparative study of blood cell count in four automated hematology analyzers: An evaluation of the impact of preanalytical factors

• Annika Åstrand ,

  Contributed equally to this work with: Annika Åstrand, Cecilia Wingren, Claire Walton, Madelene Lindqvist, Christopher McCrae

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: annika.astrand@astrazeneca.com

  Affiliation Clinical Development, Late-stage Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

  https://orcid.org/0000-0002-4231-6682

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• Cecilia Wingren ,

  Contributed equally to this work with: Annika Åstrand, Cecilia Wingren, Claire Walton, Madelene Lindqvist, Christopher McCrae

  Roles Data curation, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Bioscience, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

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• Claire Walton ,

  Contributed equally to this work with: Annika Åstrand, Cecilia Wingren, Claire Walton, Madelene Lindqvist, Christopher McCrae

  Roles Data curation, Formal analysis, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Biometrics, Late-stage Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom

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• Johan Mattsson ,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

  ¶‡ JM, KA, LO, BB, SE, GH, GLS, AS and IP also contributed equally to this work.

  Affiliation Translational Science & Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

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• Komal Agrawal ,

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  ¶‡ JM, KA, LO, BB, SE, GH, GLS, AS and IP also contributed equally to this work.

  Affiliation Translational Science & Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

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• Madelene Lindqvist ,

  Contributed equally to this work with: Annika Åstrand, Cecilia Wingren, Claire Walton, Madelene Lindqvist, Christopher McCrae

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliation Bioscience, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

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• Lina Odqvist ,

  Roles Conceptualization, Resources, Writing – review & editing

  ¶‡ JM, KA, LO, BB, SE, GH, GLS, AS and IP also contributed equally to this work.

  Affiliation Bioscience, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

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• Björn Burmeister ,

  Roles Data curation, Methodology, Writing – review & editing

  ¶‡ JM, KA, LO, BB, SE, GH, GLS, AS and IP also contributed equally to this work.

  Affiliation Translational Science & Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

  https://orcid.org/0000-0002-6044-0089

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• Steven Eck ,

  Roles Conceptualization, Supervision, Writing – review & editing

  ¶‡ JM, KA, LO, BB, SE, GH, GLS, AS and IP also contributed equally to this work.

  Affiliation Integrated Bioanalysis, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gaithersburg, MD, United States of America

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• Glen Hughes ,

  Roles Conceptualization, Supervision, Writing – review & editing

  ¶‡ JM, KA, LO, BB, SE, GH, GLS, AS and IP also contributed equally to this work.

  Affiliation Precision Medicine Unit, Biopharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom

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• Gabriela Luporini Saraiva ,

  Roles Conceptualization, Writing – review & editing

  ¶‡ JM, KA, LO, BB, SE, GH, GLS, AS and IP also contributed equally to this work.

  Affiliation Clinical Development, Late-stage Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, United States of America

  https://orcid.org/0000-0002-2131-8013

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• Anna Schantz ,

  Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

  ¶‡ JM, KA, LO, BB, SE, GH, GLS, AS and IP also contributed equally to this work.

  Affiliation Clinical Development, Late-stage Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

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• Ioannis Psallidas ,

  Roles Conceptualization, Writing – review & editing

  ¶‡ JM, KA, LO, BB, SE, GH, GLS, AS and IP also contributed equally to this work.

  Affiliation Clinical Development, Late-stage Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom

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• Christopher McCrae

  Contributed equally to this work with: Annika Åstrand, Cecilia Wingren, Claire Walton, Madelene Lindqvist, Christopher McCrae

  Roles Conceptualization, Resources, Supervision, Writing – review & editing

  Affiliation Translational Science & Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, United States of America

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