Mutations in the F protein of the live-attenuated respiratory syncytial virus vaccine candidate ΔNS2/Δ1313/I1314L increase the stability of infectivity and content of prefusion F protein

• Judith Alamares-Sapuay,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  Affiliation Sanofi, Cambridge, Massachusetts, United States of America

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• Michael Kishko,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Sanofi, Cambridge, Massachusetts, United States of America

  https://orcid.org/0000-0001-5678-3583

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• Charles Lai,

  Roles Data curation, Investigation, Methodology

  Affiliation Sanofi, Cambridge, Massachusetts, United States of America

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• Mark Parrington,

  Roles Supervision, Writing – review & editing

  Affiliation Sanofi, Cambridge, Massachusetts, United States of America

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• Simon Delagrave,

  Roles Supervision, Writing – review & editing

  Current address: Delagrave Life Sciences Consulting, Sudbury, Massachusetts, United States of America

  Affiliation Sanofi, Cambridge, Massachusetts, United States of America

  https://orcid.org/0000-0003-0865-2196

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• Richard Herbert,

  Roles Data curation, Investigation, Methodology

  Affiliation Experimental Primate Virology Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Poolesville, Maryland, United States of America

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• Ashley Castens,

  Roles Data curation, Investigation, Methodology

  Affiliation Experimental Primate Virology Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Poolesville, Maryland, United States of America

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• Joanna Swerczek,

  Roles Data curation, Investigation, Methodology

  Affiliation Experimental Primate Virology Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Poolesville, Maryland, United States of America

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• Cindy Luongo,

  Roles Data curation, Investigation, Methodology

  Affiliation RNA Viruses Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Lijuan Yang,

  Roles Data curation, Investigation, Methodology

  Affiliation RNA Viruses Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Peter L. Collins,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation RNA Viruses Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Ursula J. Buchholz,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation RNA Viruses Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Linong Zhang

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: Linong.Zhang@sanofi.com

  Affiliation Sanofi, Cambridge, Massachusetts, United States of America

  https://orcid.org/0000-0002-8863-8900

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