Rauwolfia polysaccharide can inhibit the progress of ulcerative colitis through NOS2-mediated JAK2/STAT3 pathway

Haidong Wu; Fan Jiang; Wei Yuan; Ye Zhao; Ning Liu; Xinpu Miao

doi:10.1371/journal.pone.0301660

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Open Access

Peer-reviewed

Research Article

Rauwolfia polysaccharide can inhibit the progress of ulcerative colitis through NOS2-mediated JAK2/STAT3 pathway

Haidong Wu ,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft

¶‡ HW and FJ joint last authors on this work.

Affiliation Department of Gastroenterology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China
⨯
Fan Jiang ,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft

¶‡ HW and FJ joint last authors on this work.

Affiliations Medical Centre for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China, Department of the Center of Gerontology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China
⨯
Wei Yuan,

Roles Data curation, Software, Writing – review & editing

Affiliation Department of Emergency Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China
⨯
Ye Zhao,

Roles Data curation, Software, Writing – review & editing

Affiliation Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
⨯
Ning Liu,

Roles Data curation, Writing – review & editing

Affiliation Department of Gastrointestinal Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China
⨯
Xinpu Miao

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: miaoxinpu2023@163.com

Affiliation Department of Gastroenterology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China

https://orcid.org/0009-0005-5091-1587

⨯

Rauwolfia polysaccharide can inhibit the progress of ulcerative colitis through NOS2-mediated JAK2/STAT3 pathway

Haidong Wu,
Fan Jiang,
Wei Yuan,
Ye Zhao,
Ning Liu,
Xinpu Miao

Published: April 16, 2024
https://doi.org/10.1371/journal.pone.0301660

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