Phenotypic high-throughput screening identifies aryl hydrocarbon receptor agonism as common inhibitor of toxin-induced retinal pigment epithelium cell death

Joshua Schustak; Hongwei Han; Kyle Bond; Qian Huang; Magali Saint-Geniez; Yi Bao

doi:10.1371/journal.pone.0301239

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Open Access

Peer-reviewed

Research Article

Phenotypic high-throughput screening identifies aryl hydrocarbon receptor agonism as common inhibitor of toxin-induced retinal pigment epithelium cell death

Joshua Schustak,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation Department of Ophthalmology, BioMedical Research, Novartis, Cambridge, Massachusetts, United States of America
⨯
Hongwei Han,

Roles Data curation, Investigation, Validation, Writing – review & editing

Affiliation Department of Ophthalmology, BioMedical Research, Novartis, Cambridge, Massachusetts, United States of America
⨯
Kyle Bond,

Roles Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Ophthalmology, BioMedical Research, Novartis, Cambridge, Massachusetts, United States of America

https://orcid.org/0000-0002-7277-8845

⨯
Qian Huang,

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision

Affiliation Department of Ophthalmology, BioMedical Research, Novartis, Cambridge, Massachusetts, United States of America
⨯
Magali Saint-Geniez,

Roles Investigation, Resources, Supervision, Writing – review & editing

Affiliation Department of Ophthalmology, BioMedical Research, Novartis, Cambridge, Massachusetts, United States of America

https://orcid.org/0000-0001-9897-138X

⨯
Yi Bao

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Software, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: yi.bao@novartis.com

Affiliation Department of Ophthalmology, BioMedical Research, Novartis, Cambridge, Massachusetts, United States of America

https://orcid.org/0000-0003-0748-1575

⨯

Phenotypic high-throughput screening identifies aryl hydrocarbon receptor agonism as common inhibitor of toxin-induced retinal pigment epithelium cell death

Joshua Schustak,
Hongwei Han,
Kyle Bond,
Qian Huang,
Magali Saint-Geniez,
Yi Bao

Published: April 18, 2024
https://doi.org/10.1371/journal.pone.0301239

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Apoptosis
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Necrotic cell death
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Cell death
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Toxins
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Cell staining
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Macular degeneration
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Ophthalmology
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