PAI-1 mediates acquired resistance to MET-targeted therapy in non-small cell lung cancer

Yin Min Thu; Ken Suzawa; Shuta Tomida; Kosuke Ochi; Shimpei Tsudaka; Fumiaki Takatsu; Keiichi Date; Naoki Matsuda; Kazuma Iwata; Kentaro Nakata; Kazuhiko Shien; Hiromasa Yamamoto; Mikio Okazaki; Seiichiro Sugimoto; Shinichi Toyooka

doi:10.1371/journal.pone.0300644

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Open Access

Peer-reviewed

Research Article

PAI-1 mediates acquired resistance to MET-targeted therapy in non-small cell lung cancer

Yin Min Thu,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

https://orcid.org/0009-0004-9005-2943

⨯
Ken Suzawa ,

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: ksuzawa@okayama-u.ac.jp

Affiliation Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

https://orcid.org/0000-0003-2463-9696

⨯
Shuta Tomida,

Roles Data curation, Formal analysis, Project administration, Software, Visualization, Writing – review & editing

Affiliation Center for Comprehensive Genomic Medicine, Okayama University Hospital, Okayama, Japan
⨯
Kosuke Ochi,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Shimpei Tsudaka,

Roles Formal analysis, Writing – review & editing

Affiliation Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Fumiaki Takatsu,

Roles Formal analysis, Writing – review & editing

Affiliation Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Keiichi Date,

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – review & editing

Affiliation Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Naoki Matsuda,

Roles Formal analysis, Writing – review & editing

Affiliation Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Kazuma Iwata,

Roles Formal analysis, Writing – review & editing

Affiliation Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Kentaro Nakata,

Roles Formal analysis, Writing – review & editing

Affiliation Department of Surgery, Division of Cardiovascular and Thoracic Surgery, Duke University School of Medicine, Durham, North Carolina, United States of America
⨯
Kazuhiko Shien,

Roles Formal analysis, Supervision, Writing – review & editing

Affiliation Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

https://orcid.org/0000-0002-4959-4220

⨯
Hiromasa Yamamoto,

Roles Formal analysis, Supervision, Writing – review & editing

Affiliation Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Mikio Okazaki,

Roles Formal analysis, Writing – review & editing

Affiliation Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

https://orcid.org/0000-0002-7202-244X

⨯
Seiichiro Sugimoto,

Roles Formal analysis, Writing – review & editing

Affiliation Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

https://orcid.org/0000-0001-6649-4777

⨯
Shinichi Toyooka

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliation Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯

PAI-1 mediates acquired resistance to MET-targeted therapy in non-small cell lung cancer

Yin Min Thu,
Ken Suzawa,
Shuta Tomida,
Kosuke Ochi,
Shimpei Tsudaka,
Fumiaki Takatsu,
Keiichi Date,
Naoki Matsuda,
Kazuma Iwata,
Kentaro Nakata

Published: May 17, 2024
https://doi.org/10.1371/journal.pone.0300644

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Lung and intrathoracic tumors
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Non-small cell lung cancer
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MAPK signaling cascades
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Apoptosis
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Cancer treatment
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Gene expression
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Drug therapy
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RNA analysis
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