A randomised controlled trial of Pre-Operative Oncotype DX testing in early-stage breast cancer (PRE-DX study) – Study protocol

• Matthew Northgraves ,

  Roles Conceptualization, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

  * E-mail: matthew.northgraves@hyms.ac.uk

  Affiliation Hull Health Trials Unit, University of Hull, Hull, United Kingdom

  https://orcid.org/0000-0001-9260-8643

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• Judith Cohen,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Hull Health Trials Unit, University of Hull, Hull, United Kingdom

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• James Harvey,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliations Nightingale Breast Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom

  https://orcid.org/0000-0002-1359-2186

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• Chao Huang,

  Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

  Affiliations Hull Health Trials Unit, University of Hull, Hull, United Kingdom, Institute for Clinical and Applied Health Research (ICAHR), University of Hull, Hull, United Kingdom

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• Carlo Palmieri,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliations Institute of Systems, Molecular and Integrative Biology, Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom, The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, United Kingdom

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• Sarah Pinder,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliations School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom, Department of Cellular Pathology, Guy’s and St Thomas NHS Foundation Trust, London, United Kingdom

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• Pankaj Roy,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Department of Breast Surgery, Oxford University Hospitals NHS Foundation Trust, Oxfordshire, United Kingdom

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• Sarah Reynia,

  Roles Conceptualization, Writing – review & editing

  Affiliation Exact Sciences UK, London, United Kingdom

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• Marta Soares,

  Roles Conceptualization, Formal analysis, Writing – review & editing

  Affiliation Centre for Health Economics, University of York, York, United Kingdom

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• Henry Cain

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

  Affiliation Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom

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