Discovery of anti-SARS-CoV-2 S2 protein antibody CV804 with broad-spectrum reactivity with various beta coronaviruses and analysis of its pharmacological properties in vitro and in vivo

• Yoji Tsugawa ,

  Contributed equally to this work with: Yoji Tsugawa, Kentaro Furukawa

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: yoji.tsugawa@shionogi.co.jp (YT); Tatsuya.takahashi@shionogi.co.jp (TT)

  Affiliation Shionogi Pharmaceutical Research Center, Osaka, Japan

  https://orcid.org/0000-0001-5896-373X

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• Kentaro Furukawa ,

  Contributed equally to this work with: Yoji Tsugawa, Kentaro Furukawa

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft

  Affiliations Shionogi Pharmaceutical Research Center, Osaka, Japan, Laboratory of Antibody Design, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan

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• Tomoko Ise,

  Roles Data curation, Formal analysis, Resources, Validation

  Affiliation Laboratory of Antibody Design, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan

  ⨯
• Masahiro Takayama,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliation Shionogi Pharmaceutical Research Center, Osaka, Japan

  ⨯
• Takeshi Ota,

  Roles Data curation, Investigation, Methodology

  Affiliation Shionogi Pharmaceutical Research Center, Osaka, Japan

  ⨯
• Takayuki Kuroda,

  Roles Validation, Visualization

  Affiliation Shionogi Pharmaceutical Research Center, Osaka, Japan

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• Shinya Shano,

  Roles Validation, Visualization

  Affiliation Shionogi TechnoAdvance Research, Co., Ltd., Osaka, Japan

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• Takashi Hashimoto,

  Roles Validation

  Affiliation Shionogi TechnoAdvance Research, Co., Ltd., Osaka, Japan

  ⨯
• Haruyo Konishi,

  Roles Validation

  Affiliation Shionogi Pharmaceutical Research Center, Osaka, Japan

  ⨯
• Takeshi Ishihara,

  Roles Validation

  Affiliation Shionogi Pharmaceutical Research Center, Osaka, Japan

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• Masaaki Sato,

  Roles Validation

  Affiliation Shionogi Pharmaceutical Research Center, Osaka, Japan

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• Haruhiko Kamada,

  Roles Validation

  Affiliation Laboratory of Antibody Design, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan

  https://orcid.org/0000-0002-2478-3818

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• Keita Fukao,

  Roles Data curation, Investigation, Supervision, Validation, Visualization, Writing – original draft

  Affiliation Shionogi Pharmaceutical Research Center, Osaka, Japan

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• Takao Shishido,

  Roles Project administration, Supervision

  Affiliation Shionogi Pharmaceutical Research Center, Osaka, Japan

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• Mai Yoshikawa,

  Roles Formal analysis, Investigation, Supervision, Validation

  Affiliation Shionogi Pharmaceutical Research Center, Osaka, Japan

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• Tatsuya Takahashi ,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Supervision

  * E-mail: yoji.tsugawa@shionogi.co.jp (YT); Tatsuya.takahashi@shionogi.co.jp (TT)

  Affiliation Shionogi Pharmaceutical Research Center, Osaka, Japan

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•  [ ... ],
• Satoshi Nagata

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Laboratory of Antibody Design, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan

  https://orcid.org/0000-0001-9156-5215

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