Autocrine phosphatase PDP2 inhibits ferroptosis by dephosphorylating ACSL4 in the Luminal A Breast Cancer

Jun-Jie Zhu; Feng-Ying Huang; Hengyu Chen; Yun-long Zhang; Ming-Hui Chen; Ri-Hong Wu; Shu-Zhen Dai; Gui-Sheng He; Guang-Hong Tan; Wu-Ping Zheng

doi:10.1371/journal.pone.0299571

Loading metrics

Open Access

Peer-reviewed

Research Article

Autocrine phosphatase PDP2 inhibits ferroptosis by dephosphorylating ACSL4 in the Luminal A Breast Cancer

Jun-Jie Zhu ,

Contributed equally to this work with: Jun-Jie Zhu, Feng-Ying Huang

Roles Investigation, Writing – original draft

Affiliation Department of Breast and Thyroid Surgery, The Second Affiliated Hospital and Key Laborato1y of Tropical Translational Medicine of Ministry of Education & School of Tropical Medicine, Hainan Medical University, Haikou, China
⨯
Feng-Ying Huang ,

Contributed equally to this work with: Jun-Jie Zhu, Feng-Ying Huang

Roles Investigation, Methodology, Writing – original draft

Affiliation Department of Breast and Thyroid Surgery, The Second Affiliated Hospital and Key Laborato1y of Tropical Translational Medicine of Ministry of Education & School of Tropical Medicine, Hainan Medical University, Haikou, China
⨯
Hengyu Chen,

Roles Investigation, Methodology

Affiliation Department of Breast and Thyroid Surgery, The Second Affiliated Hospital and Key Laborato1y of Tropical Translational Medicine of Ministry of Education & School of Tropical Medicine, Hainan Medical University, Haikou, China
⨯
Yun-long Zhang,

Roles Investigation

Affiliation Department of Breast and Thyroid Surgery, The Second Affiliated Hospital and Key Laborato1y of Tropical Translational Medicine of Ministry of Education & School of Tropical Medicine, Hainan Medical University, Haikou, China
⨯
Ming-Hui Chen,

Roles Investigation

Affiliation Department of Breast and Thyroid Surgery, The Second Affiliated Hospital and Key Laborato1y of Tropical Translational Medicine of Ministry of Education & School of Tropical Medicine, Hainan Medical University, Haikou, China
⨯
Ri-Hong Wu,

Roles Investigation

Affiliation Department of Breast and Thyroid Surgery, The Second Affiliated Hospital and Key Laborato1y of Tropical Translational Medicine of Ministry of Education & School of Tropical Medicine, Hainan Medical University, Haikou, China
⨯
Shu-Zhen Dai,

Roles Investigation, Methodology

Affiliation Department of Breast and Thyroid Surgery, The Second Affiliated Hospital and Key Laborato1y of Tropical Translational Medicine of Ministry of Education & School of Tropical Medicine, Hainan Medical University, Haikou, China
⨯
Gui-Sheng He,

Roles Conceptualization, Data curation, Methodology, Writing – original draft

Affiliation Department of Breast and Thyroid Surgery, The Second Affiliated Hospital and Key Laborato1y of Tropical Translational Medicine of Ministry of Education & School of Tropical Medicine, Hainan Medical University, Haikou, China
⨯
Guang-Hong Tan ,

Roles Funding acquisition, Methodology, Supervision, Writing – review & editing

* E-mail: tanhoho@163.com (GHT); hnzwp2000@163.com (WPZ)

Affiliation Department of Breast and Thyroid Surgery, The Second Affiliated Hospital and Key Laborato1y of Tropical Translational Medicine of Ministry of Education & School of Tropical Medicine, Hainan Medical University, Haikou, China
⨯
Wu-Ping Zheng

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Supervision, Writing – review & editing

* E-mail: tanhoho@163.com (GHT); hnzwp2000@163.com (WPZ)

Affiliation Department of Breast and Thyroid Surgery, The Second Affiliated Hospital and Key Laborato1y of Tropical Translational Medicine of Ministry of Education & School of Tropical Medicine, Hainan Medical University, Haikou, China

https://orcid.org/0000-0003-0259-0457

⨯

Autocrine phosphatase PDP2 inhibits ferroptosis by dephosphorylating ACSL4 in the Luminal A Breast Cancer

Jun-Jie Zhu,
Feng-Ying Huang,
Hengyu Chen,
Yun-long Zhang,
Ming-Hui Chen,
Ri-Hong Wu,
Shu-Zhen Dai,
Gui-Sheng He,
Guang-Hong Tan,
Wu-Ping Zheng

Published: March 11, 2024
https://doi.org/10.1371/journal.pone.0299571

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Phosphatases
Is the Subject Area "Phosphatases" applicable to this article?

Thanks for your feedback.
Phosphorylation
Is the Subject Area "Phosphorylation" applicable to this article?

Thanks for your feedback.
Breast cancer
Is the Subject Area "Breast cancer" applicable to this article?

Thanks for your feedback.
Flow cytometry
Is the Subject Area "Flow cytometry" applicable to this article?

Thanks for your feedback.
Lipid peroxidation
Is the Subject Area "Lipid peroxidation" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Prognosis
Is the Subject Area "Prognosis" applicable to this article?

Thanks for your feedback.
Peroxides
Is the Subject Area "Peroxides" applicable to this article?

Thanks for your feedback.