A novel micellular fluorogenic substrate for quantitating the activity of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma (PLCγ) enzymes

• Ramya Visvanathan,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Institute for Drug Discovery, Purdue University, West Lafayette, IN, United States of America, IUSM-Purdue TREAT-AD Center, West Lafayette, IN, United States of America, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, United States of America

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• Tadanobu Utsuki,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Institute for Drug Discovery, Purdue University, West Lafayette, IN, United States of America, IUSM-Purdue TREAT-AD Center, West Lafayette, IN, United States of America

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• Daniel E. Beck,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Institute for Drug Discovery, Purdue University, West Lafayette, IN, United States of America, IUSM-Purdue TREAT-AD Center, West Lafayette, IN, United States of America

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• W. Brent Clayton,

  Roles Investigation, Methodology

  Affiliations IUSM-Purdue TREAT-AD Center, West Lafayette, IN, United States of America, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN, United States of America

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• Emma Lendy,

  Roles Investigation

  Affiliations IUSM-Purdue TREAT-AD Center, West Lafayette, IN, United States of America, Department of Biochemistry, Purdue University, West Lafayette, IN, United States of America

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• Kuai-lin Sun,

  Roles Investigation

  Affiliation Cayman Chemical Company, Ann Arbor, MI, United States of America

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• Yinghui Liu,

  Roles Investigation

  Affiliation Cayman Chemical Company, Ann Arbor, MI, United States of America

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• Kirk W. Hering,

  Roles Supervision

  Affiliation Cayman Chemical Company, Ann Arbor, MI, United States of America

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• Andrew Mesecar,

  Roles Funding acquisition, Methodology, Supervision

  Affiliations IUSM-Purdue TREAT-AD Center, West Lafayette, IN, United States of America, Department of Biochemistry, Purdue University, West Lafayette, IN, United States of America

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• Zhong-Yin Zhang,

  Roles Funding acquisition, Methodology, Supervision

  Affiliations Institute for Drug Discovery, Purdue University, West Lafayette, IN, United States of America, IUSM-Purdue TREAT-AD Center, West Lafayette, IN, United States of America, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, United States of America

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• Karson S. Putt

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: puttk@purdue.edu

  Affiliations Institute for Drug Discovery, Purdue University, West Lafayette, IN, United States of America, IUSM-Purdue TREAT-AD Center, West Lafayette, IN, United States of America

  https://orcid.org/0000-0003-0619-2616

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