Efficacy of Shu-yi-ning-chang decoction on IBS-D: Modulating Nr4a3 pathway to reduce visceral hypersensitivity

Yajing Guo; Qiongqiong Lu; Xiao-Jun Yang; Yuxi He; Yue Wu; Baijun Qin; Ting Li; Min Duan; Nvping Liu; Xin Wu; Yuanjun He

doi:10.1371/journal.pone.0299376

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Open Access

Peer-reviewed

Research Article

Efficacy of Shu-yi-ning-chang decoction on IBS-D: Modulating Nr4a3 pathway to reduce visceral hypersensitivity

Yajing Guo,

Roles Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China
⨯
Qiongqiong Lu,

Roles Funding acquisition, Supervision

Affiliation Department of Gastroenterology, Chongqing City Hospital of Traditional Chinese Medicine, Chongqing, China
⨯
Xiao-Jun Yang ,

Roles Conceptualization, Funding acquisition, Investigation, Supervision

* E-mail: yangxj88@126.com

Affiliations Department of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China, Department of Gastroenterology, Chongqing City Hospital of Traditional Chinese Medicine, Chongqing, China

https://orcid.org/0000-0003-0119-5930

⨯
Yuxi He,

Roles Methodology

Affiliation Department of Gastroenterology, Chongqing City Hospital of Traditional Chinese Medicine, Chongqing, China
⨯
Yue Wu,

Roles Project administration, Resources

Affiliation Department of Gastroenterology, Chongqing City Hospital of Traditional Chinese Medicine, Chongqing, China
⨯
Baijun Qin,

Roles Supervision

Affiliation Department of Gastroenterology, Chongqing City Hospital of Traditional Chinese Medicine, Chongqing, China
⨯
Ting Li,

Roles Resources, Software

Affiliation Department of Pharmaceutical, Chongqing Medical University, Chongqing, China
⨯
Min Duan,

Roles Methodology, Project administration

Affiliation Department of Clinical medicine, Changsha Hospital of Traditional Chinese Medicine Affiliated to Hunan University of Traditional Chinese Medicine, Changsha, Hunan, China
⨯
Nvping Liu,

Roles Methodology, Project administration

Affiliation Department of Clinical medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China
⨯
Xin Wu,

Roles Methodology, Project administration

Affiliation Department of Clinical medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China
⨯
Yuanjun He

Roles Project administration

Affiliation Department of Gastroenterology, Chongqing City Hospital of Traditional Chinese Medicine, Chongqing, China
⨯

Efficacy of Shu-yi-ning-chang decoction on IBS-D: Modulating Nr4a3 pathway to reduce visceral hypersensitivity

Yajing Guo,
Qiongqiong Lu,
Xiao-Jun Yang,
Yuxi He,
Yue Wu,
Baijun Qin,
Ting Li,
Min Duan,
Nvping Liu,
Xin Wu

Published: April 17, 2024
https://doi.org/10.1371/journal.pone.0299376

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